P00390 | GSHR_HUMAN | Glutathione reductase, mitochondrial (GSR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02852 | Pyr_redox_dim - Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | 411~521 | |
| PF07992 | Pyr_redox_2 - Pyridine nucleotide-disulphide oxidoreductase | 65~390 |
3D structures mapped by conservation among orthologs
[ Domain: "FAD/NAD-linked reduatases, dimerisation (C-terminal) domain" // Pyr_redox_dim ]
[ Domain: "FAD/NAD(P)-binding domain" // Pyr_redox_2_1 ]
[ Domain: "FAD/NAD(P)-binding domain" // Pyr_redox_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL120147 |  |
IC50 | = | 4.1 | nM | 339.31 | O=C(Cc1ccc2ccccc2c1)NNC(=O)c1ccc([N+](=O)[O-])o1 | Homo sapiens | CHEMBL881411 | single protein format |
| CHEMBL1824793 |  |
IC50 | = | 344.0 | nM | 296.24 | O=C(O)CC[C@H](NC(=O)c1ccc([N+](=O)[O-])cc1)C(=O)O | Homo sapiens | CHEMBL1825434 | single protein format |
| CHEMBL135536 |  |
IC50 | = | 750.0 | nM | 302.33 | CC1=C(CCCCCC(=O)O)C(=O)c2c(O)cccc2C1=O | Homo sapiens | CHEMBL685507 | single protein format |
| CHEMBL39225 |  |
IC50 | = | 1000.0 | nM | 358.28 | O=c1nc2n(-c3cccc(C(F)(F)F)c3)c3ccccc3nc-2c(=O)[nH]1 | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL287849 |  |
IC50 | = | 1000.0 | nM | 372.31 | Cn1c(=O)nc2n(-c3cccc(C(F)(F)F)c3)c3ccccc3nc-2c1=O | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL39137 |  |
IC50 | = | 1000.0 | nM | 356.74 | Cn1c(=O)nc2n(-c3ccc(Cl)cc3)c3cc(F)ccc3nc-2c1=O | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL135504 |  |
IC50 | = | 1000.0 | nM | 288.3 | CC1=C(CCCCC(=O)O)C(=O)c2c(O)cccc2C1=O | Homo sapiens | CHEMBL685507 | single protein format |
| CHEMBL40675 |  |
IC50 | < | 1000.0 | nM | 338.75 | Cn1c(=O)nc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2c1=O | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL288269 |  |
IC50 | < | 1000.0 | nM | 373.2 | Cn1c(=O)nc2n(-c3cc(Cl)cc(Cl)c3)c3ccccc3nc-2c1=O | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL287816 |  |
IC50 | < | 1000.0 | nM | 359.17 | O=c1nc2n(-c3cc(Cl)cc(Cl)c3)c3ccccc3nc-2c(=O)[nH]1 | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL39141 |  |
IC50 | < | 1000.0 | nM | 324.73 | O=c1nc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2c(=O)[nH]1 | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL446394 |  |
IC50 | < | 1000.0 | nM | 394.26 | Cn1c(=O)nc2n(-c3c(F)c(F)c(F)c(F)c3F)c3ccccc3nc-2c1=O | Homo sapiens | CHEMBL685508 | single protein format |
| CHEMBL1824793 | |
Ki | = | 211.0 | nM | 296.24 | O=C(O)CC[C@H](NC(=O)c1ccc([N+](=O)[O-])cc1)C(=O)O | Homo sapiens | CHEMBL1825435 | single protein format |