P00338 | LDHA_HUMAN | L-lactate dehydrogenase A chain (LDHA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00056 | Ldh_1_N - lactate/malate dehydrogenase, NAD binding domain | 22~160 | |
| PF02866 | Ldh_1_C - lactate/malate dehydrogenase, alpha/beta C-terminal domain | 164~324 |
3D structures mapped by conservation among orthologs
[ Domain: "LDH C-terminal domain-like" // Ldh_1_C_13 ]
[ Domain: "NAD(P)-binding Rossmann-fold domains" // Ldh_1_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5181996 |  |
IC50 | = | 2.2 | nM | 430.93 | O=C1OC(c2ccsc2)(c2ccccc2O)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138278 | single protein format |
| CHEMBL5176448 |  |
IC50 | = | 2.9 | nM | 525.03 | O=C1OC(c2ccsc2)(c2cccc(Nc3ccc(F)cn3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138278 | single protein format |
| CHEMBL5182266 |  |
IC50 | = | 2.9 | nM | 525.03 | O=C1OC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)n2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138278 | single protein format |
| CHEMBL4786682 |  |
IC50 | = | 3.0 | nM | 598.65 | NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CCCO)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1F | Homo sapiens | CHEMBL4670705 | single protein format |
| CHEMBL4576717 |  |
IC50 | = | 3.0 | nM | 523.05 | O=C1NC(c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL5177632 |  |
IC50 | = | 4.0 | nM | 524.04 | O=C1O[C@@](c2ccsc2)(c2cccc(Nc3ccc(F)cc3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL5138278 | single protein format |
| CHEMBL4435570 |  |
IC50 | = | 4.0 | nM | 511.11 | O=C1NC(c2ccsc2)(c2cccc(NC3CCCCC3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL3335792 |  |
IC50 | = | 5.0 | nM | 499.06 | O=C1CC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)NC(=O)C1Sc1ccccc1Cl | Homo sapiens | CHEMBL3386528 | single protein format |
| CHEMBL4467769 |  |
IC50 | = | 5.0 | nM | 540.11 | CC(=O)N1CCN(c2ccc(C3(c4ccsc4)CC(O)=C(Sc4ccccc4Cl)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL3581197 |  |
IC50 | = | 6.0 | nM | 561.91 | C[C@@H](OC(=O)Cc1ccc(Cl)c(SC2=C(O)CC(c3c(Cl)cccc3Cl)CC2=O)c1)c1ccccc1 | Homo sapiens | CHEMBL3583864 | single protein format |
| CHEMBL4444963 |  |
IC50 | = | 7.0 | nM | 483.06 | O=C1NC(c2ccc(N3CCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL4876783 |  |
IC50 | = | 8.0 | nM | 586.64 | NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(OC4CC4)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1F | Homo sapiens | CHEMBL4817965 | single protein format |
| CHEMBL4847105 |  |
IC50 | = | 8.0 | nM | 542.61 | COc1cc(-c2nn(-c3nc(C(=O)O)cs3)c(CC3CC3)c2Cc2ccc(S(N)(=O)=O)cc2)ccc1F | Homo sapiens | CHEMBL4817965 | single protein format |
| CHEMBL4783945 |  |
IC50 | = | 8.0 | nM | 598.65 | COCC#Cc1cc(-c2nn(-c3nc(C(=O)O)cs3)c(CC3CC3)c2Cc2ccc(S(N)(=O)=O)c(F)c2)ccc1F | Homo sapiens | CHEMBL4670705 | single protein format |
| CHEMBL4520899 |  |
IC50 | = | 9.0 | nM | 497.09 | O=C1NC(c2ccc(N3CCCCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL4436150 |  |
IC50 | = | 9.0 | nM | 499.06 | O=C1NC(c2ccc(N3CCOCC3)cc2)(c2ccsc2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL4545064 |  |
IC50 | = | 9.0 | nM | 513.08 | O=C1NC(c2ccsc2)(c2cccc(NC3CCOCC3)c2)CC(O)=C1Sc1ccccc1Cl | Homo sapiens | CHEMBL4431228 | single protein format |
| CHEMBL4777867 |  |
IC50 | = | 9.0 | nM | 594.67 | NS(=O)(=O)c1ccc(Cc2c(-c3ccc(F)c(C#CC4CC4)c3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1F | Homo sapiens | CHEMBL4670705 | single protein format |
| CHEMBL4059985 |  |
IC50 | = | 9.0 | nM | 494.6 | NS(=O)(=O)c1ccc(Cc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2CC2CC2)cc1 | Homo sapiens | CHEMBL4032329 | assay format |
| CHEMBL4783252 |  |
IC50 | = | 9.0 | nM | 550.64 | CC#Cc1cccc(-c2nn(-c3nc(C(=O)O)cs3)c(CC3CC3)c2Cc2ccc(S(N)(=O)=O)c(F)c2)c1 | Homo sapiens | CHEMBL4670705 | single protein format |