O96028 | NSD2_HUMAN | Histone-lysine N-methyltransferase NSD2 (NSD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00505 | HMG_box - HMG (high mobility group) box | 457~506 | |
| PF00628 | PHD - PHD-finger | 834~872 | |
| PF00855 | PWWP - PWWP domain | 223~303 | |
| PF00855 | PWWP - PWWP domain | 882~969 | |
| PF00856 | SET - SET domain | 1074~1180 | |
| PF17907 | AWS - AWS domain | 1022~1060 | |
| PF17982 | C5HCH - NSD Cys-His rich domain | 1282~1327 | |
| PF22908 | PHD_NSD - Histone-lysine N-methyltransferase NSD-like, PHD zinc finger | 714~762 | |
| PF23004 | PHDvar_NSD - Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger | 764~816 | |
| PF23011 | PHD-1st_NSD - Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | 663~711 | |
| PF23011 | PHD-1st_NSD - Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | 1239~1280 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Domain: "SET domain-like" // SET ]
[ Domain: "Zn3Cys9 preSET domain-related" // AWS ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5438639 |  |
IC50 | = | 12.0 | nM | 475.53 | CNC(=O)[C@@]1(N)CCCN(c2cnc(-c3cccc(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5388295 | cell-based format |
| CHEMBL5422710 |  |
IC50 | = | 18.0 | nM | 513.56 | Nc1ncnc2c1ncn2Cc1cc(-c2ccc(F)c(F)c2)ncc1N1CCC[C@](N)(c2ccccn2)C1 | Homo sapiens | CHEMBL5388295 | cell-based format |
| CHEMBL5437594 |  |
IC50 | = | 40.0 | nM | 520.59 | CC[C@H](C)C(=O)[C@@]1(N)CCCN(c2cnc(-c3ccc(F)c(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5388295 | cell-based format |
| CHEMBL5200945 |  |
IC50 | = | 104.0 | nM | 443.46 | O=C1COc2cc(C(=O)N(Cc3ccc(C(=O)Nc4ccncn4)cc3)C3CC3)ccc2N1 | Homo sapiens | CHEMBL5318925 | single protein format |
| CHEMBL5186268 |  |
IC50 | = | 110.0 | nM | 449.6 | Cc1cc(CN2CCC(N)CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 | Homo sapiens | CHEMBL5124717 | assay format |
| CHEMBL5406268 |  |
IC50 | = | 200.0 | nM | 439.85 | O=C1C(Cl)=C(NCCC2(O)CCN(C(=O)C3CC3(F)F)CC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL131199 |  |
IC50 | = | 210.0 | nM | 324.77 | O=C1C(Cl)=C(NC2CCc3ccccc32)C(=O)c2ncccc21 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5422549 |  |
IC50 | = | 230.0 | nM | 355.78 | CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL337173 |  |
IC50 | = | 230.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5418169 |  |
IC50 | = | 240.0 | nM | 475.85 | C[C@@](O)(C(=O)N1CCC(O)(CCNC2=C(Cl)C(=O)c3cccnc3C2=O)CC1)C(F)(F)F | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5412847 |  |
IC50 | = | 250.0 | nM | 347.17 | CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2ccc(Cl)nc2C1=O | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5415704 |  |
IC50 | = | 250.0 | nM | 355.78 | CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4cccnc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5433538 |  |
IC50 | = | 300.0 | nM | 312.73 | CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2cccnc2C1=O | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5402620 |  |
IC50 | = | 300.0 | nM | 381.77 | CC(F)(F)C(=O)NC12CC(NC3=C(Cl)C(=O)c4cccnc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5401066 |  |
IC50 | = | 310.0 | nM | 329.74 | CC#CC(=O)NC1CN(C2=C(Cl)C(=O)c3cccnc3C2=O)C1 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5419286 |  |
IC50 | = | 330.0 | nM | 409.82 | CC(F)(F)C(=O)N1CCC2(CC1)CN(C1=C(Cl)C(=O)c3cccnc3C1=O)C2 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5418912 |  |
IC50 | = | 330.0 | nM | 381.77 | CC(F)(F)C(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5419919 |  |
IC50 | = | 360.0 | nM | 381.84 | CC(C)(O)[C@H](F)CNC1=C(Cl)C(=O)c2ccc(N3CCCC3)nc2C1=O | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5402868 |  |
IC50 | = | 360.0 | nM | 355.73 | CC(F)(F)C(=O)NC1CN(C2=C(Cl)C(=O)c3ncccc3C2=O)C1 | Homo sapiens | CHEMBL5318855 | single protein format |
| CHEMBL5436306 |  |
IC50 | = | 380.0 | nM | 383.78 | CC(F)(F)C(=O)NCCC1CN(C2=C(Cl)C(=O)c3cccnc3C2=O)C1 | Homo sapiens | CHEMBL5318855 | single protein format |