O96017 | CHK2_HUMAN | Serine/threonine-protein kinase Chk2 (CHEK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 222~486 | |
| PF00498 | FHA - FHA domain | 113~191 |
3D structures mapped by conservation among orthologs
[ Domain: "SMAD/FHA domain" // FHA ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL195041 |  |
IC50 | = | 2.3 | nM | 361.43 | NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(O)cc4)cc3)nc2c1 | Homo sapiens | CHEMBL874429 | single protein format |
| CHEMBL3980850 |  |
IC50 | = | 3.0 | nM | 373.84 | C=C(c1ccc(Cl)cc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL1236782 |  |
IC50 | = | 3.0 | nM | 442.49 | COc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC | Homo sapiens | CHEMBL1663817 | single protein format |
| CHEMBL195177 |  |
IC50 | = | 3.4 | nM | 461.33 | NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(Cl)c(Cl)c4)cc3)nc2c1 | Homo sapiens | CHEMBL874429 | single protein format |
| CHEMBL3894962 |  |
IC50 | = | 4.0 | nM | 424.25 | NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Br)c(O)c4)cc3)nc2c1 | Homo sapiens | CHEMBL3882739 | single protein format |
| CHEMBL3949796 |  |
IC50 | = | 4.0 | nM | 361.83 | NC(=O)c1ccc2[nH]c(-c3ccc(Cc4ccc(Cl)cc4)cc3)nc2c1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL3958697 |  |
IC50 | = | 4.0 | nM | 397.86 | NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(F)c(Cl)c4)cc3)nc2c1 | Homo sapiens | CHEMBL3882739 | single protein format |
| CHEMBL3935794 |  |
IC50 | = | 4.0 | nM | 445.83 | NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL359881 |  |
IC50 | = | 4.4 | nM | 377.83 | Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1Cl | Homo sapiens | CHEMBL874429 | single protein format |
| CHEMBL179717 |  |
IC50 | = | 4.5 | nM | 431.8 | NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 | Homo sapiens | CHEMBL874429 | single protein format |
| CHEMBL3930129 |  |
IC50 | = | 5.0 | nM | 375.86 | CC(c1ccc(Cl)cc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL3933085 |  |
IC50 | = | 5.0 | nM | 393.45 | NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc5ccccc5c4)cc3)nc2c1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL3947096 |  |
IC50 | = | 5.0 | nM | 377.45 | NC(=O)c1ccc2[nH]c(-c3ccc(Cc4ccc5ccccc5c4)cc3)nc2c1 | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL3904143 |  |
IC50 | = | 5.0 | nM | 355.44 | Cc1ccc(Cc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1C | Homo sapiens | CHEMBL3882742 | single protein format |
| CHEMBL1650128 |  |
IC50 | = | 5.0 | nM | 486.54 | COCCOc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC | Homo sapiens | CHEMBL1663817 | single protein format |
| CHEMBL3956891 |  |
IC50 | = | 5.0 | nM | 438.28 | COc1cc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)ccc1Br | Homo sapiens | CHEMBL3882739 | single protein format |
| CHEMBL3917001 |  |
IC50 | = | 5.0 | nM | 375.45 | COc1ccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 | Homo sapiens | CHEMBL3882739 | single protein format |
| CHEMBL5176837 |  |
IC50 | = | 5.1 | nM | 389.46 | COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 | Homo sapiens | CHEMBL5150848 | single protein format |
| CHEMBL175553 |  |
IC50 | = | 5.5 | nM | 398.25 | NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(Cl)c4)cc3)nc2c1 | Homo sapiens | CHEMBL874429 | single protein format |
| CHEMBL4072515 |  |
IC50 | = | 5.5 | nM | 544.57 | Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)NCc5ccccc5)ccc4[nH]3)cc2)c1[N+](=O)[O-] | Homo sapiens | CHEMBL4034965 | single protein format |