O95977 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor 4 (S1PR4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 63~307 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL474689 |  |
IC50 | = | 1.1 | nM | 425.47 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 | Homo sapiens | CHEMBL1029037 | single protein format |
| CHEMBL470511 |  |
IC50 | = | 1.23 | nM | 459.48 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL432067 |  |
IC50 | = | 1.7 | nM | 357.43 | CCCCCCCCc1ccc(CCC(N)COP(=O)(O)O)cc1 | Homo sapiens | CHEMBL806184 | cell-based format |
| CHEMBL474688 |  |
IC50 | = | 1.8 | nM | 420.42 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 | Homo sapiens | CHEMBL1029037 | single protein format |
| CHEMBL473269 |  |
IC50 | = | 1.9 | nM | 443.46 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | Homo sapiens | CHEMBL1029037 | single protein format |
| CHEMBL1093429 |  |
IC50 | = | 3.4 | nM | 538.46 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL1108114 | cell-based format |
| CHEMBL515921 |  |
IC50 | = | 3.5 | nM | 420.42 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F | Homo sapiens | CHEMBL1029037 | single protein format |
| CHEMBL473156 |  |
IC50 | = | 3.6 | nM | 436.45 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL475495 |  |
IC50 | = | 4.0 | nM | 402.43 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 | Homo sapiens | CHEMBL1029037 | single protein format |
| CHEMBL475405 |  |
IC50 | = | 4.17 | nM | 470.46 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL1093823 |  |
IC50 | = | 4.4 | nM | 547.47 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | Homo sapiens | CHEMBL1108114 | cell-based format |
| CHEMBL514170 |  |
IC50 | = | 4.9 | nM | 479.47 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL473238 |  |
IC50 | = | 5.24 | nM | 484.49 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL473563 |  |
IC50 | = | 6.15 | nM | 456.44 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL1090829 |  |
IC50 | = | 6.5 | nM | 561.5 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | Homo sapiens | CHEMBL1108114 | cell-based format |
| CHEMBL473562 |  |
IC50 | = | 8.3 | nM | 428.47 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL184879 |  |
IC50 | = | 8.4 | nM | 381.5 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | Homo sapiens | CHEMBL833012 | cell-based format |
| CHEMBL514302 |  |
IC50 | = | 10.3 | nM | 422.42 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL515917 |  |
IC50 | = | 11.7 | nM | 445.46 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 | Homo sapiens | CHEMBL980650 | single protein format |
| CHEMBL1090796 |  |
IC50 | = | 13.1 | nM | 482.47 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL1108114 | cell-based format |