O95835 | LATS1_HUMAN | Serine/threonine-protein kinase LATS1 (LATS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 706~854 | |
| PF00069 | Pkinase - Protein kinase domain | 904~1010 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 1030~1080 | |
| PF00627 | UBA - UBA/TS-N domain | 101~138 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4571918 |  |
IC50 | = | 0.0 | nM | 316.37 | CC1(Nc2nc(-c3ccnc4[nH]ccc34)nc3cnccc23)CC1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4439972 |  |
IC50 | = | 0.7 | nM | 322.42 | CC(C)(N)C(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420663 | single protein format |
| CHEMBL4447153 |  |
IC50 | = | 0.8 | nM | 308.39 | CC(C)(CN)CNc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420663 | single protein format |
| CHEMBL4525078 |  |
IC50 | = | 0.8 | nM | 339.45 | Cc1n[nH]cc1-c1nc(NC(C)(C)CCN(C)C)c2ccncc2n1 | Homo sapiens | CHEMBL4420663 | single protein format |
| CHEMBL4463018 |  |
IC50 | = | 0.9 | nM | 305.38 | C[C@@H]1CCC[C@@H]1Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4577658 |  |
IC50 | = | 1.0 | nM | 322.42 | NCCCCCCNc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4571192 |  |
IC50 | = | 1.0 | nM | 333.32 | CC(C)(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4517252 |  |
IC50 | = | 1.0 | nM | 331.3 | FC(F)(F)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CC1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4564805 |  |
IC50 | = | 1.0 | nM | 336.44 | CN(C)CCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4576185 |  |
IC50 | = | 1.0 | nM | 348.33 | FC(F)(F)c1n[nH]cc1-c1nc(NC2CCCC2)c2ccncc2n1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4444109 |  |
IC50 | = | 1.0 | nM | 281.36 | Cc1n[nH]cc1-c1cc(NC(C)(C)C)c2ccncc2n1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4472306 |  |
IC50 | = | 1.0 | nM | 293.37 | CCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4577857 |  |
IC50 | = | 1.0 | nM | 345.33 | FC(F)(F)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4454440 |  |
IC50 | = | 1.0 | nM | 278.36 | CC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4518582 |  |
IC50 | = | 1.0 | nM | 309.37 | CC(C)(CCO)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4555291 |  |
IC50 | = | 1.0 | nM | 351.31 | CC(C)(Nc1nc(-c2ccncc2F)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4467179 |  |
IC50 | = | 1.0 | nM | 291.36 | CC1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4533967 |  |
IC50 | = | 1.0 | nM | 337.43 | CC(C)(O)CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4551441 |  |
IC50 | = | 1.0 | nM | 279.35 | CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420660 | single protein format |
| CHEMBL4547932 |  |
IC50 | = | 1.0 | nM | 291.36 | Cc1nccc2c(NC3(C)CC3)nc(-c3ccncc3)nc12 | Homo sapiens | CHEMBL4420660 | single protein format |