O95822 | DCMC_HUMAN | Malonyl-CoA decarboxylase, mitochondrial (MLYCD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05292 | MCD - Malonyl-CoA decarboxylase C-terminal domain | 193~456 | |
| PF17408 | MCD_N - Malonyl-CoA decarboxylase N-terminal domain | 95~190 |
3D structures mapped by conservation among orthologs
[ Domain: "Mitochondrial malonyl-CoA decarboxylase helical domain" // MCD_N ]
[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // MCD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL205986 |  |
IC50 | = | 0.07 | nM | 399.38 | CC(C)CN(CC(C)C)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL380487 |  |
IC50 | = | 0.29 | nM | 368.28 | CCN(CCC#N)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1258253 |  |
IC50 | = | 0.5 | nM | 497.42 | NC(=O)C1(c2cccc(C(=O)O)c2)CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)s2)CC1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1258254 |  |
IC50 | = | 0.6 | nM | 498.4 | O=C(O)c1cccc(C2(C(=O)O)CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)s3)CC2)c1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL205506 |  |
IC50 | = | 0.85 | nM | 341.25 | O=C(c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)N1CCCC1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1257549 |  |
IC50 | = | 0.9 | nM | 454.39 | O=C(O)c1cccc(C2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)s3)CC2)c1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1258367 |  |
IC50 | = | 0.9 | nM | 531.5 | CS(=O)(=O)NC(=O)C1(c2ccccc2)CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)s2)CC1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL204287 |  |
IC50 | = | 0.98 | nM | 355.28 | O=C(c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)N1CCCCC1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL202688 |  |
IC50 | = | 1.0 | nM | 391.31 | CN(Cc1ccccc1)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1257909 |  |
IC50 | = | 1.1 | nM | 454.39 | O=C(O)C1(c2ccccc2)CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)s2)CC1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL206852 |  |
IC50 | = | 1.14 | nM | 357.25 | O=C(c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)N1CCOCC1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1258699 |  |
IC50 | = | 1.3 | nM | 455.38 | O=C(O)c1cccc(N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)s3)CC2)c1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1258139 |  |
IC50 | = | 1.4 | nM | 472.38 | O=C(O)C1(c2ccc(F)cc2)CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)s2)CC1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL202689 |  |
IC50 | = | 1.45 | nM | 331.21 | CON(C)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1258935 |  |
IC50 | = | 1.6 | nM | 479.41 | OC(c1cnc(N2CCN(c3cccc(-c4nnn[nH]4)c3)CC2)s1)(C(F)(F)F)C(F)(F)F | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1258140 |  |
IC50 | = | 1.6 | nM | 496.41 | OC(c1cnc(N2CCC(c3nnn[nH]3)(c3ccccc3F)CC2)s1)(C(F)(F)F)C(F)(F)F | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1257548 |  |
IC50 | = | 1.7 | nM | 454.39 | O=C(O)c1ccccc1C1CCN(c2ncc(C(O)(C(F)(F)F)C(F)(F)F)s2)CC1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL1257669 |  |
IC50 | = | 1.8 | nM | 453.41 | NC(=O)c1cccc(C2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)s3)CC2)c1 | Homo sapiens | CHEMBL1261133 | single protein format |
| CHEMBL202746 |  |
IC50 | = | 1.99 | nM | 405.34 | CN(CCc1ccccc1)C(=O)c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL859660 | single protein format |
| CHEMBL1258820 |  |
IC50 | = | 2.2 | nM | 454.4 | NC(=O)c1cccc(N2CCN(c3ncc(C(O)(C(F)(F)F)C(F)(F)F)s3)CC2)c1 | Homo sapiens | CHEMBL1261133 | single protein format |