O95819 | M4K4_HUMAN | Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 25~289 | |
| PF00780 | CNH - CNH domain | 935~1208 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4793665 |  |
IC50 | = | 0.09 | nM | 395.53 | CCN1CCC(c2ncc(-c3cnc(N)c(OCc4ccncc4)c3)s2)CC1 | Homo sapiens | CHEMBL4674070 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.57 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328443 | single protein format |
| CHEMBL4787152 |  |
IC50 | = | 0.6 | nM | 408.89 | Nc1ncc(-c2ccc(OC3(C(=O)O)CCCC3)cc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4759743 |  |
IC50 | = | 1.0 | nM | 368.82 | C[C@H](Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4750540 |  |
IC50 | = | 1.3 | nM | 383.83 | CC(C)(Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1)C(=O)O | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4781045 |  |
IC50 | = | 1.4 | nM | 366.85 | CC(C)(C(=O)O)c1cccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)c1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL3623135 |  |
IC50 | = | 1.4 | nM | 322.34 | Nc1ncc(C(=O)NC2CC2)c2ccc(-c3cccc(F)c3)nc12 | Homo sapiens | CHEMBL3624922 | single protein format |
| CHEMBL4783711 |  |
IC50 | = | 1.4 | nM | 364.83 | Nc1ncc(-c2ccc3c(c2)CC[C@@H]3C(=O)O)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL3623139 |  |
IC50 | = | 1.6 | nM | 394.41 | CNC(=O)N1CC(NC(=O)c2cnc(N)c3nc(-c4cccc(F)c4)ccc23)C1 | Homo sapiens | CHEMBL3624922 | single protein format |
| CHEMBL4740167 |  |
IC50 | = | 2.0 | nM | 382.85 | CC(C)(Oc1cccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)c1)C(=O)O | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4779507 |  |
IC50 | = | 2.0 | nM | 354.79 | Nc1ncc(-c2ccc(OCC(=O)O)cc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4787142 |  |
IC50 | = | 2.0 | nM | 408.89 | Nc1ncc(-c2ccc(C3(C(=O)O)CCOCC3)cc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4745446 |  |
IC50 | = | 2.1 | nM | 401.88 | CS(=O)(=O)NC(=O)c1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4751017 |  |
IC50 | = | 2.4 | nM | 354.8 | Nc1ncc(-c2ccc(NCC(=O)O)nc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4757082 |  |
IC50 | = | 2.4 | nM | 324.77 | Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4283353 |  |
IC50 | = | 2.7 | nM | 504.72 | CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 | Homo sapiens | CHEMBL4838725 | cell-based format |
| CHEMBL4777705 |  |
IC50 | = | 2.9 | nM | 416.92 | Nc1ncc(-c2ccc(C3(c4nn[nH]n4)CCCC3)cc2)cc1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4800212 |  |
IC50 | = | 3.5 | nM | 320.35 | COc1ccc(-c2cc(-c3ccc(C(=O)O)cc3)cnc2N)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL4788172 |  |
IC50 | = | 3.5 | nM | 358.32 | Nc1ncc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL4681994 | assay format |
| CHEMBL3623137 |  |
IC50 | = | 3.5 | nM | 393.42 | CCC(=O)N1CC(NC(=O)c2cnc(N)c3nc(-c4cccc(F)c4)ccc23)C1 | Homo sapiens | CHEMBL3624922 | single protein format |