O95749 | GGPPS_HUMAN | Geranylgeranyl pyrophosphate synthase (GGPS1)

Pfam Domain Table

AccessionDomainRangeColor
PF00348polyprenyl_synt - Polyprenyl synthetase10~250

3D structures mapped by conservation among orthologs

[ Domain: "Terpenoid synthases" // polyprenyl_synt ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5395051 IC50 = 8.0 nM 572.33 O=C(Nc1ccc(C(F)(F)F)cc1)c1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3cn[nH]c3n2)c1 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5397309 IC50 = 12.0 nM 588.4 O=C(Nc1ccc(C(F)(F)F)cc1)c1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5412066 IC50 = 12.0 nM 586.36 Cn1ncc2c(NC(P(=O)(O)O)P(=O)(O)O)nc(-c3cccc(C(=O)Nc4ccc(C(F)(F)F)cc4)c3)nc21 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5429622 IC50 = 13.0 nM 586.36 Cn1cnc2c(NC(P(=O)(O)O)P(=O)(O)O)nc(-c3cccc(C(=O)Nc4ccc(C(F)(F)F)cc4)c3)nc21 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5397879 IC50 = 18.0 nM 538.39 O=C(Nc1ccc(F)cc1)c1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5094672 IC50 = 18.0 nM 588.4 O=C(Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1)c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL5048363 assay format
CHEMBL5077349 IC50 = 21.0 nM 552.42 Cc1ccc(C(=O)Nc2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4ccsc4n3)c2)cc1F Homo sapiens CHEMBL5048363 assay format
CHEMBL5077117 IC50 = 21.0 nM 592.51 CC(C)O[C@H](C(=O)Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1)c1ccccc1 Homo sapiens CHEMBL5048363 assay format
CHEMBL5075557 IC50 = 23.0 nM 534.43 O=C(Cc1ccccc1)Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1 Homo sapiens CHEMBL5048363 assay format
CHEMBL5089506 IC50 = 23.0 nM 592.51 CC(C)O[C@@H](C(=O)Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1)c1ccccc1 Homo sapiens CHEMBL5048363 assay format
CHEMBL5085126 IC50 = 23.0 nM 588.47 Cc1ccc(S(=O)(=O)Nc2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4ccsc4n3)c2)cc1F Homo sapiens CHEMBL5048363 assay format
CHEMBL5436148 IC50 = 25.0 nM 552.35 COc1ccc(NC(=O)c2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4cn[nH]c4n3)c2)cc1F Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5088555 IC50 = 29.0 nM 568.42 COc1ccc(C(=O)Nc2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4ccsc4n3)c2)cc1F Homo sapiens CHEMBL5048363 assay format
CHEMBL5434884 IC50 = 29.0 nM 550.38 CCn1ncc2c(NC(P(=O)(O)O)P(=O)(O)O)nc(-c3cccc(C(=O)Nc4ccc(F)cc4)c3)nc21 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5426733 IC50 = 30.0 nM 564.41 CC(C)n1ncc2c(NC(P(=O)(O)O)P(=O)(O)O)nc(-c3cccc(C(=O)Nc4ccc(F)cc4)c3)nc21 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5432841 IC50 = 31.0 nM 536.35 Cn1ncc2c(NC(P(=O)(O)O)P(=O)(O)O)nc(-c3cccc(C(=O)Nc4ccc(F)cc4)c3)nc21 Homo sapiens CHEMBL5376798 cell-based format
CHEMBL5075029 IC50 = 31.0 nM 552.42 Cc1ccc(NC(=O)c2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4ccsc4n3)c2)cc1F Homo sapiens CHEMBL5048363 assay format
CHEMBL5080121 IC50 = 34.0 nM 583.43 COc1ccc(NC(=O)Nc2cccc(-c3nc(NC(P(=O)(O)O)P(=O)(O)O)c4ccsc4n3)c2)cc1F Homo sapiens CHEMBL5048363 assay format
CHEMBL5082291 IC50 = 38.0 nM 564.45 CO[C@H](C(=O)Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1)c1ccccc1 Homo sapiens CHEMBL5048363 assay format
CHEMBL5081807 IC50 = 39.0 nM 564.45 CO[C@@H](C(=O)Nc1cccc(-c2nc(NC(P(=O)(O)O)P(=O)(O)O)c3ccsc3n2)c1)c1ccccc1 Homo sapiens CHEMBL5048363 assay format