O95602 | RPA1_HUMAN | DNA-directed RNA polymerase I subunit RPA1 (POLR1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00623 | RNA_pol_Rpb1_2 - RNA polymerase Rpb1, domain 2 | 434~613 | |
| PF04983 | RNA_pol_Rpb1_3 - RNA polymerase Rpb1, domain 3 | 617~802 | |
| PF04997 | RNA_pol_Rpb1_1 - RNA polymerase Rpb1, domain 1 | 11~355 | |
| PF04998 | RNA_pol_Rpb1_5 - RNA polymerase Rpb1, domain 5 | 958~1667 | |
| PF05000 | RNA_pol_Rpb1_4 - RNA polymerase Rpb1, domain 4 | 841~951 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3289424 |  |
IC50 | = | 40.0 | nM | 374.44 | CC(CNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12)N(C)C | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL3289398 |  |
IC50 | = | 50.0 | nM | 360.42 | CN(C)CCNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL3289421 |  |
IC50 | = | 90.0 | nM | 386.46 | O=C(NCCN1CCCC1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL3289423 |  |
IC50 | = | 110.0 | nM | 374.44 | CC(CN(C)C)NC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL3289422 |  |
IC50 | = | 140.0 | nM | 388.47 | CCN(CC)CCNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL5091256 |  |
IC50 | = | 160.0 | nM | 360.42 | CN(C)CCNC(=O)c1cccn2c(=O)c3ccc4ccccc4c3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL3289414 |  |
IC50 | = | 180.0 | nM | 386.46 | CN1CCC(NC(=O)c2cccn3c(=O)c4cc5ccccc5cc4nc23)CC1 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL3289420 |  |
IC50 | = | 180.0 | nM | 400.48 | O=C(NCCN1CCCCC1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL5091818 |  |
IC50 | = | 210.0 | nM | 386.46 | O=C(NCCN1CCCC1)c1cccn2c(=O)c3ccc4ccccc4c3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL3289413 |  |
IC50 | = | 210.0 | nM | 344.37 | O=C(NC1CNC1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL5093823 |  |
IC50 | = | 420.0 | nM | 416.38 | O=C(NCCN1CCCC1)c1cccn2c(=O)c3cc4c(cc3nc12)OC(F)(F)O4 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL3289410 |  |
IC50 | = | 430.0 | nM | 374.44 | CN(C)CCCNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |
| CHEMBL5072152 |  |
IC50 | = | 470.0 | nM | 346.39 | CNCCNC(=O)c1cccn2c(=O)c3ccc4ccccc4c3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5076121 |  |
IC50 | = | 540.0 | nM | 380.4 | O=C(NCCN1CCCC1)c1cccn2c(=O)c3cc4c(cc3nc12)OCO4 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5088110 |  |
IC50 | = | 590.0 | nM | 386.46 | O=C(NCC1CCCCN1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5089364 |  |
IC50 | = | 600.0 | nM | 432.48 | O=C(NCCN1CCC(O)(O)CC1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5074659 |  |
IC50 | = | 600.0 | nM | 388.47 | CCN(CC)CCNC(=O)c1cccn2c(=O)c3ccc4ccccc4c3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5091051 |  |
IC50 | = | 640.0 | nM | 400.48 | O=C(NCCN1CCCCC1)c1cccn2c(=O)c3ccc4ccccc4c3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL5094886 |  |
IC50 | = | 650.0 | nM | 416.48 | O=C(NCC1CCCC(CO)N1)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL5038526 | tissue-based format |
| CHEMBL3289409 |  |
IC50 | = | 660.0 | nM | 388.47 | CN(C)CCCCNC(=O)c1cccn2c(=O)c3cc4ccccc4cc3nc12 | Homo sapiens | CHEMBL3291669 | cell-based format |