O95551 | TYDP2_HUMAN | Tyrosyl-DNA phosphodiesterase 2 (TDP2)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF03372Exo_endo_phos117–351
PF14555UBA_430–63

 3D structures mapped by conservation among orthologs

[ Domain: "DNase I-like" // Exo_endo_phos ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL65 IC50 = 0.0 nM 348.36 CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1 Homo sapiens CHEMBL4040007 single protein format
CHEMBL4441013 IC50 = 6.1 nM 517.95 CS(=O)(=O)Nc1cccc(-n2c3nc(=O)n(-c4ccc(Cl)cc4)c(=O)c-3cc3ccc(C#N)cc32)c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4572376 IC50 = 6.5 nM 517.95 CS(=O)(=O)Nc1ccc(-n2c3nc(=O)n(-c4ccc(Cl)cc4)c(=O)c-3cc3ccc(C#N)cc32)cc1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4436202 IC50 = 7.3 nM 440.85 N#Cc1ccc2cc3c(=O)n(-c4ccc(Cl)cc4)c(=O)nc-3n(-c3cccc(O)c3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4587441 IC50 = 14.0 nM 475.29 N#Cc1ccc2cc3c(=O)n(-c4ccc(Cl)c(Cl)c4)c(=O)nc-3n(-c3cccc(O)c3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4520052 IC50 = 20.0 nM 440.85 N#Cc1ccc2cc3c(=O)n(-c4cccc(Cl)c4)c(=O)nc-3n(-c3cccc(O)c3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4560735 IC50 = 33.0 nM 406.4 N#Cc1ccc2cc3c(=O)n(-c4ccccc4)c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4468174 IC50 = 33.0 nM 440.85 N#Cc1ccc2cc3c(=O)n(-c4ccc(Cl)cc4)c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4555612 IC50 = 35.0 nM 449.43 N#Cc1ccc2cc3c(=O)n(-c4cccc(C(N)=O)c4)c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4521151 IC50 = 38.0 nM 464.44 COC(=O)c1cccc(-n2c(=O)nc3n(-c4ccc(O)cc4)c4cc(C#N)ccc4cc-3c2=O)c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4470500 IC50 = 40.0 nM 189.17 NC1=CC(N)=C2C=CC(=O)N=C2C1=O Homo sapiens CHEMBL4372320 single protein format
CHEMBL4457155 IC50 = 65.0 nM 485.3 N#Cc1ccc2cc3c(=O)n(-c4ccc(Br)cc4)c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4546104 IC50 = 70.0 nM 424.39 N#Cc1ccc2cc3c(=O)n(-c4ccc(F)cc4)c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4518508 IC50 = 130.0 nM 464.44 N#Cc1ccc2cc3c(=O)[nH]c(=O)nc-3n(-c3ccc(OCc4cccc(C(=O)O)c4)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL2420465 IC50 = 140.0 nM 330.3 N#Cc1ccc2cc3c(=O)[nH]c(=O)nc-3n(-c3ccc(O)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4576353 IC50 = 150.0 nM 478.46 COC(=O)c1cccc(COc2ccc(-n3c4nc(=O)[nH]c(=O)c-4cc4ccc(C#N)cc43)cc2)c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL1325945 IC50 = 161.1 nM 235.25 CCCc1nc2c(=O)n(C)c(=O)nc-2n(C)n1 Homo sapiens CHEMBL3215006 single protein format
CHEMBL4557001 IC50 = 190.0 nM 450.41 N#Cc1ccc2cc3c(=O)[nH]c(=O)nc-3n(-c3ccc(Oc4cccc(C(=O)O)c4)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL4464179 IC50 = 200.0 nM 420.43 N#Cc1ccc2cc3c(=O)[nH]c(=O)nc-3n(-c3ccc(OCc4ccccc4)cc3)c2c1 Homo sapiens CHEMBL4386568 single protein format
CHEMBL1463659 IC50 = 210.04 nM 270.25 Cn1nc(-c2ccccn2)nc2c(=O)n(C)c(=O)nc1-2 Homo sapiens CHEMBL3215006 single protein format