O95497 | VNN1_HUMAN | Pantetheinase (VNN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00795 | CN_hydrolase - Carbon-nitrogen hydrolase | 55~234 | |
| PF19018 | Vanin_C - Vanin C-terminal domain | 333~483 |
3D structures mapped by conservation among orthologs
[ Domain: "Hyaluronate lyase-like, C-terminal domain" // EUF07815 ]
[ Domain: "Carbon-nitrogen hydrolase" // CN_hydrolase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5089503 |  |
IC50 | = | 0.04 | nM | 380.45 | O=C(c1cnc(NC2(c3cnccn3)CCC2)nc1)N1CC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5084938 |  |
IC50 | = | 0.04 | nM | 394.48 | O=C(c1cnc(NC2(c3cnccn3)CCC2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5085625 |  |
IC50 | = | 0.06 | nM | 382.47 | CC(C)(Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5082540 |  |
IC50 | = | 0.08 | nM | 382.47 | CC(C)(Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cncnc1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5072128 |  |
IC50 | = | 0.11 | nM | 368.44 | CC(C)(Nc1ncc(C(=O)N2CC3(CCOCC3)C2)cn1)c1cnccn1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5087511 |  |
IC50 | = | 0.12 | nM | 394.48 | O=C(c1cnc(NC2(c3cncnc3)CCC2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5088348 |  |
IC50 | = | 0.24 | nM | 368.44 | C[C@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5087956 |  |
IC50 | = | 0.28 | nM | 380.45 | O=C(c1cnc(NC2(c3cncnc3)CC2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5081075 |  |
IC50 | = | 0.35 | nM | 396.45 | O=C(c1cnc(NC2(c3cnccn3)COC2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5092354 |  |
IC50 | = | 0.43 | nM | 396.45 | O=C(c1cnc(NC2(c3cncnc3)COC2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5083289 |  |
IC50 | = | 0.6 | nM | 354.41 | C[C@H](Nc1ncc(C(=O)N2CC3(CCOCC3)C2)cn1)c1cnccn1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5082701 |  |
IC50 | = | 0.68 | nM | 368.44 | C[C@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cncnc1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5074743 |  |
IC50 | = | 1.3 | nM | 353.43 | O=C(c1cnc(NCc2cccnc2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5090508 |  |
IC50 | = | 3.12 | nM | 368.44 | C[C@@H](Nc1ncc(C(=O)N2CCC3(CCOCC3)C2)cn1)c1cnccn1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5092194 |  |
IC50 | = | 3.4 | nM | 340.39 | O=C(c1cnc(NCc2cnccn2)nc1)N1CC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5092926 |  |
IC50 | = | 4.1 | nM | 342.36 | N#Cc1cccc(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)c1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5071943 |  |
IC50 | = | 4.4 | nM | 315.34 | N#Cc1cccc(C(=O)c2cnc(NCc3cccnc3)nc2)c1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL4802040 |  |
IC50 | = | 6.85 | nM | 354.41 | O=C(c1cnc(NCc2cnccn2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL4880310 | single protein format |
| CHEMBL5094296 |  |
IC50 | = | 7.7 | nM | 354.41 | O=C(c1cnc(NCc2cncnc2)nc1)N1CCC2(CCOCC2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |
| CHEMBL5091378 |  |
IC50 | = | 10.4 | nM | 349.4 | N#CC1CCCN(C(=O)c2cnc(NC3(c4cncnc4)CC3)nc2)C1 | Homo sapiens | CHEMBL5047674 | cell-based format |