O95470 | SGPL1_HUMAN | Sphingosine-1-phosphate lyase 1 (SGPL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00282 | Pyridoxal_deC - Pyridoxal-dependent decarboxylase conserved domain | 196~448 |
3D structures mapped by conservation among orthologs
[ Domain: "C-terminal domain in some PLP-dependent transferases" // KOG1383 ]
[ Domain: "PLP-dependent transferases" // Aminotran_5_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3290335 |  |
IC50 | = | 24.0 | nM | 445.53 | C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(C#N)cc23)CCN1c1ccc(C#N)cn1 | Homo sapiens | CHEMBL3293781 | cell-based format |
| CHEMBL3290333 |  |
IC50 | = | 100.0 | nM | 488.52 | C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(C(F)(F)F)cc23)CCN1c1ccc(C#N)cn1 | Homo sapiens | CHEMBL3293781 | cell-based format |
| CHEMBL3798814 |  |
IC50 | = | 117.0 | nM | 435.57 | CCCCOc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3798147 |  |
IC50 | = | 150.0 | nM | 447.54 | COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(C#CCO)cc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3799061 |  |
IC50 | = | 150.0 | nM | 478.59 | COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(CCCC(N)=O)cc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3290331 |  |
IC50 | = | 210.0 | nM | 454.97 | C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(Cl)cc23)CCN1c1ccc(C#N)cn1 | Homo sapiens | CHEMBL3293781 | cell-based format |
| CHEMBL3799085 |  |
IC50 | = | 260.0 | nM | 407.51 | CCOc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3798254 |  |
IC50 | = | 485.0 | nM | 393.49 | COc1cc(C)c(CNC[C@@H](NC(=O)c2cc(C)on2)c2ccccc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3798874 |  |
IC50 | = | 590.0 | nM | 461.48 | Cc1cc(C(=O)NC(CNCc2cc(C)c(OCC(F)(F)F)cc2C)c2ccccc2)no1 | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3797779 |  |
IC50 | = | 720.0 | nM | 411.48 | COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccc(F)cc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3798062 |  |
IC50 | = | 730.0 | nM | 419.53 | COc1cc(C)c(CNCC(NC(=O)c2cc(C3CC3)on2)c2ccccc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3290322 |  |
IC50 | = | 740.0 | nM | 440.51 | C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccccc23)CCN1c1ccc([N+](=O)[O-])cn1 | Homo sapiens | CHEMBL3293781 | cell-based format |
| CHEMBL3799254 |  |
IC50 | = | 850.0 | nM | 394.48 | COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccncc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3798106 |  |
IC50 | = | 1000.0 | nM | 470.57 | Cc1cc(C(=O)NC(CNCc2cc(C)c(OCc3ccncc3)cc2C)c2ccccc2)no1 | Homo sapiens | CHEMBL3803908 | single protein format |
| CHEMBL3799908 |  |
IC50 | = | 1000.0 | nM | 393.49 | COc1cc(C)c(CNCC(NC(=O)c2cc(C)on2)c2ccccc2)cc1C | Homo sapiens | CHEMBL3803908 | single protein format |