O95382 | M3K6_HUMAN | Mitogen-activated protein kinase kinase kinase 6 (MAP3K6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 653~906 | |
| PF13281 | MAP3K_TRAF_bd - MAP3K TRAFs-binding domain | 129~507 | |
| PF19039 | ASK_PH - ASK kinase PH domain | 524~618 | |
| PF20302 | HisK-N-like - HisK-N-like globin domain of the ASK signalosome | 993~1122 | |
| PF20309 | DRHyd-ASK - Deoxyribohydrolase (DRHyd) domain of the ASK signalosome | 74~114 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4763562 |  |
IC50 | = | 200.8 | nM | 373.42 | CC(C)n1cnnc1-c1cccc(NC(=O)Nc2nccc3ccccc23)n1 | Homo sapiens | CHEMBL4686915 | single protein format |
| CHEMBL4764071 |  |
IC50 | = | 264.4 | nM | 389.42 | C[C@H](CO)n1cnnc1-c1cccc(NC(=O)Nc2nccc3ccccc23)n1 | Homo sapiens | CHEMBL4686915 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 475.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328494 | single protein format |
| CHEMBL2205637 |  |
IC50 | = | 510.0 | nM | 395.89 | CC(C)(C)c1ccc(C(=O)Nc2cn3cc(-n4ccnc4)ccc3n2)cc1.Cl | Homo sapiens | CHEMBL2214714 | single protein format |
| CHEMBL4778541 |  |
IC50 | = | 510.0 | nM | 432.36 | CC(C)(C)c1ccc(C(=O)Nc2cn3cc(-n4ccnc4)ccc3n2)cc1.Cl.Cl | Homo sapiens | CHEMBL5468239 | single protein format |
| CHEMBL4759182 |  |
IC50 | = | 742.4 | nM | 364.37 | CC(C)n1cnnc1-c1cccc(NC(=O)Nc2ncc3[nH]cnc3n2)n1 | Homo sapiens | CHEMBL4686915 | single protein format |