O95271 | TNKS1_HUMAN | Poly [ADP-ribose] polymerase tankyrase-1 (TNKS)

Pfam Domain Table

AccessionDomainRangeColor
PF00023Ank - Ankyrin repeat282~312
PF00023Ank - Ankyrin repeat436~465
PF00023Ank - Ankyrin repeat751~780
PF00023Ank - Ankyrin repeat904~933
PF00644PARP - Poly(ADP-ribose) polymerase catalytic domain1116~1281
PF07647SAM_2 - SAM domain (Sterile alpha motif)1030~1086
PF12796Ank_2 - Ankyrin repeats (3 copies)186~279
PF12796Ank_2 - Ankyrin repeats (3 copies)339~432
PF12796Ank_2 - Ankyrin repeats (3 copies)539~618
PF12796Ank_2 - Ankyrin repeats (3 copies)654~747
PF12796Ank_2 - Ankyrin repeats (3 copies)807~900

3D structures mapped by conservation among orthologs

[ Domain: "SAM domain-like" // SAM_1 ]

 PyMOL session

[ Domain: "Ankyrin repeat" // Ank_2 ]

 PyMOL session

[ Domain: "ADP-ribosylation" // PARP ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3110100 IC50 = 0.1 nM 448.55 N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110117 IC50 = 0.1 nM 475.57 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110122 IC50 = 0.1 nM 457.98 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccc(Cl)cc2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3805896 IC50 = 0.18 nM 435.52 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4c(C)ccc4c(=O)[nH]3)CC2)cc1 Homo sapiens CHEMBL3807233 single protein format
CHEMBL3110103 IC50 = 0.2 nM 457.98 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2cccc(Cl)c2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110104 IC50 = 0.2 nM 448.55 N#Cc1cccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)c1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3806163 IC50 = 0.2 nM 439.49 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cc1 Homo sapiens CHEMBL3807233 single protein format
CHEMBL3110102 IC50 = 0.2 nM 424.53 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccccn2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110101 IC50 = 0.2 nM 424.53 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccncc2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110119 IC50 = 0.2 nM 479.61 O=C(CCSc1nc2c(c(=O)[nH]1)CCCC2)N[C@H]1CC[C@H](c2nnc(-c3ccccc3)o2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110121 IC50 = 0.2 nM 441.53 O=C(CCSc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@H](Oc2ccc(F)cc2)CC1 Homo sapiens CHEMBL3111843 single protein format
CHEMBL3110106 IC50 = 0.2 nM 482.99 N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1Cl Homo sapiens CHEMBL3111843 single protein format
CHEMBL3805393 IC50 = 0.24 nM 440.48 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cn1 Homo sapiens CHEMBL3807233 single protein format
CHEMBL4645574 IC50 = 0.26 nM 463.53 CCN(C(=O)N1CCC(C(=O)c2ccc3c(c2)cc(C(=O)O)n3C)CC1)c1ccc(OC)cc1 Homo sapiens CHEMBL4627147 single protein format
CHEMBL4634919 IC50 = 0.27 nM 434.5 CCN(C(=O)N1CCC(C(=O)c2ccc3cnn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4627147 single protein format
CHEMBL3110105 IC50 = 0.3 nM 482.99 N#Cc1cc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)ccc1Cl Homo sapiens CHEMBL3111843 single protein format
CHEMBL3917693 IC50 = 0.316 nM 484.56 CC1(C)OC(=O)N([C@H]2CC[C@H](c3cnc4[nH]c(=O)n(-c5ncccn5)c4c3)CC2)[C@H]1c1ccccc1 Homo sapiens CHEMBL3888461 single protein format
CHEMBL4640008 IC50 = 0.36 nM 463.53 CCN(C(=O)N1CCC(C(=O)c2ccc3cc(C(=O)O)n(C)c3c2)CC1)c1ccc(OC)cc1 Homo sapiens CHEMBL4627147 single protein format
CHEMBL4115425 IC50 = 0.375 nM 416.48 C[C@H]1OC(=O)N([C@H]2CC[C@H](n3c(=O)[nH]c4cc(C#N)ccc43)CC2)[C@H]1c1ccccc1 Homo sapiens CHEMBL3888461 single protein format
CHEMBL3804939 IC50 = 0.4 nM 467.59 COc1ccc(C(=O)C2CCN(C(=O)CCCc3nc4c(C)scc4c(=O)[nH]3)CC2)cc1C Homo sapiens CHEMBL3807233 single protein format