O95267 | GRP1_HUMAN | RAS guanyl-releasing protein 1 (RASGRP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 542~593 | |
| PF00617 | RasGEF - RasGEF domain | 208~383 | |
| PF00618 | RasGEF_N - RasGEF N-terminal motif | 58~153 |
3D structures mapped by conservation among orthologs
[ Domain: "EF-hand" // EF-hand_7_9 ]
[ Domain: "Ras GEF" // RasGEF ]
[ Domain: "Cysteine-rich domain" // C1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL519741 |  |
Ki | = | 0.25 | nM | 413.51 | CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cn(C)c3ccccc23)C(=O)O1 | Homo sapiens | CHEMBL3294522 | single protein format |
| CHEMBL3289012 |  |
Ki | = | 0.41 | nM | 413.51 | CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccc3c(ccn3C)c2)C(=O)O1 | Homo sapiens | CHEMBL3294522 | single protein format |
| CHEMBL3289014 |  |
Ki | = | 0.69 | nM | 413.51 | CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cccc3ccn(C)c23)C(=O)O1 | Homo sapiens | CHEMBL3294522 | single protein format |
| CHEMBL3289013 |  |
Ki | = | 0.87 | nM | 413.51 | CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2ccc3ccn(C)c3c2)C(=O)O1 | Homo sapiens | CHEMBL3294522 | single protein format |
| CHEMBL3289011 |  |
Ki | = | 1.55 | nM | 413.51 | CCCC(CCC)C(=O)OCC1(CO)C/C(=C\c2cccc3c2ccn3C)C(=O)O1 | Homo sapiens | CHEMBL3294522 | single protein format |
| CHEMBL4097154 |  |
Ki | = | 22.6 | nM | 505.57 | Cc1ccc(C#Cc2ccc(C=C3CC(CO)(COC(=O)c4cn(C)c5ccccc45)OC3=O)cc2)cc1 | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4070999 |  |
Ki | = | 22.6 | nM | 427.54 | CC(C)C(C/C=C1/CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)C(C)C | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4075373 |  |
Ki | = | 31.3 | nM | 427.54 | CC(C)C(C/C=C1\CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)C(C)C | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4069954 |  |
Ki | = | 40.0 | nM | 505.57 | Cc1ccc(C#Cc2ccc(/C=C3\CC(CO)(COC(=O)c4cn(C)c5ccccc45)OC3=O)cc2)cc1 | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4099579 |  |
Ki | = | 63.3 | nM | 441.57 | CCCCCCCCC/C=C1\CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4081576 |  |
Ki | = | 133.0 | nM | 413.51 | CCCC(/C=C1\CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O)CCC | Homo sapiens | CHEMBL4020950 | assay format |
| CHEMBL4066764 |  |
Ki | = | 666.0 | nM | 343.38 | CC(C)=C1CC(CO)(COC(=O)c2cn(C)c3ccccc23)OC1=O | Homo sapiens | CHEMBL4020950 | assay format |