O95263 | PDE8B_HUMAN | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 614~857 | |
| PF08629 | PDE8 - PDE8 phosphodiesterase | 1~47 | |
| PF13426 | PAS_9 - PAS domain | 281~376 | |
| PF23198 | PDE8A_N - PDE8A-like, N-terminal domain | 125~270 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1780094 |  |
IC50 | = | 0.12 | nM | 481.6 | Cc1oc(-c2ccccc2)nc1CN1C[C@H](C(=O)NCc2cccc(N)n2)C[C@@H](c2ccccc2)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL5169811 |  |
IC50 | = | 0.3 | nM | 400.39 | Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CN(Cc2nccs2)CCO1 | Homo sapiens | CHEMBL5226659 | single protein format |
| CHEMBL1779987 |  |
IC50 | = | 0.9 | nM | 480.61 | Cc1cccc(CNC(=O)[C@@H]2C[C@@H](c3ccccc3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL2070733 |  |
IC50 | = | 0.9 | nM | 372.46 | Nc1nc(C2CC2)nc2c1nnn2C[C@H]1CN(Cc2nccs2)CCO1 | Homo sapiens | CHEMBL2073616 | cell-based format |
| CHEMBL1780096 |  |
IC50 | = | 0.955 | nM | 432.57 | CC[C@H]1C[C@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL2070735 |  |
IC50 | = | 1.3 | nM | 346.42 | Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1 | Homo sapiens | CHEMBL2073616 | cell-based format |
| CHEMBL2070732 |  |
IC50 | = | 1.6 | nM | 394.36 | Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CN(Cc2ccccn2)CCO1 | Homo sapiens | CHEMBL2073616 | cell-based format |
| CHEMBL1780085 |  |
IC50 | = | 1.96 | nM | 441.57 | COC[C@@H]1C[C@@H](C(=O)NCC2CCOCC2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1780116 |  |
IC50 | = | 2.91 | nM | 411.55 | CC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1779988 |  |
IC50 | = | 3.2 | nM | 448.57 | COC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL2070914 |  |
IC50 | = | 3.63 | nM | 322.37 | Nc1nc(C2CC2)nc2c1nnn2CC1OCCc2ccccc21 | Homo sapiens | CHEMBL2073616 | cell-based format |
| CHEMBL1780100 |  |
IC50 | = | 3.86 | nM | 486.58 | Cc1cccc(CNC(=O)[C@H]2C[C@H](c3nc(C)no3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1780089 |  |
IC50 | = | 3.9 | nM | 486.58 | Cc1cccc(CNC(=O)[C@@H]2C[C@@H](c3nc(C)no3)CN(Cc3nc(-c4ccccc4)oc3C)C2)n1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL2070736 |  |
IC50 | = | 4.2 | nM | 374.47 | CCc1csc(CN2CCO[C@@H](Cn3nnc4c(N)nc(C)nc43)C2)n1 | Homo sapiens | CHEMBL2073616 | cell-based format |
| CHEMBL1780097 |  |
IC50 | = | 4.3 | nM | 448.57 | COC[C@H]1C[C@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1780105 |  |
IC50 | = | 4.36 | nM | 427.55 | COC[C@@H]1C[C@@H](C(=O)NC[C@H]2CCCO2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1780111 |  |
IC50 | = | 4.42 | nM | 433.56 | CC[C@@H]1C[C@@H](C(=O)NCc2cccc(N)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1779976 |  |
IC50 | = | 5.0 | nM | 452.56 | Cc1cccc(CNC(=O)C2CN(Cc3nc(-c4ccccc4)oc3C)Cc3ccccc32)n1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1779984 |  |
IC50 | = | 6.0 | nM | 432.57 | CC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |
| CHEMBL1779985 |  |
IC50 | = | 6.0 | nM | 446.6 | CCC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780332 | single protein format |