O95180 | CAC1H_HUMAN | Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 99~429 | |
| PF00520 | Ion_trans - Ion transport protein | 793~1021 | |
| PF00520 | Ion_trans - Ion transport protein | 1293~1565 | |
| PF00520 | Ion_trans - Ion transport protein | 1617~1870 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4205005 |  |
IC50 | = | 3.4 | nM | 370.4 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4203101 |  |
IC50 | = | 3.8 | nM | 424.45 | CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL1210565 |  |
IC50 | = | 4.0 | nM | 500.91 | O=C(Nc1cc(F)cc(F)c1)N1CCC2(CC1)C(=O)N(c1ccc(F)c(Cl)c1)C2c1ccccn1 | Homo sapiens | CHEMBL1212315 | cell-based format |
| CHEMBL4204077 |  |
IC50 | = | 4.1 | nM | 368.87 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(Cl)cc3)n2)cc1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4215974 |  |
IC50 | = | 4.3 | nM | 397.43 | CC1(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4204507 |  |
IC50 | = | 5.1 | nM | 418.42 | CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)(F)F)cc3)n2)cc1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4212039 |  |
IC50 | = | 5.3 | nM | 366.37 | O=C(Cc1ccc2cc[nH]c2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4207031 |  |
IC50 | = | 6.0 | nM | 369.42 | CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL3906825 |  |
IC50 | = | 6.0 | nM | 418.52 | C[C@@H]1CN(Cc2ccccc2)c2nc(F)ccc2[C@H](C)N1C(=O)NCc1ccccc1 | Homo sapiens | CHEMBL3865204 | cell-based format |
| CHEMBL4206509 |  |
IC50 | = | 6.1 | nM | 417.41 | O=C(Cc1ccc(C2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4202587 |  |
IC50 | = | 6.6 | nM | 402.97 | CC(C)OCc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 | Homo sapiens | CHEMBL4180613 | cell-based format |
| CHEMBL4214862 |  |
IC50 | = | 6.7 | nM | 433.41 | O=C(Cc1ccc(N2CCC(F)(F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4208907 |  |
IC50 | = | 7.0 | nM | 429.4 | Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4218608 |  |
IC50 | = | 7.5 | nM | 373.46 | CC(C)(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)cc1 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4207291 |  |
IC50 | = | 7.8 | nM | 443.43 | CCc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4216687 |  |
IC50 | = | 7.8 | nM | 400.43 | COc1c(F)cc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1F | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL1684950 |  |
IC50 | = | 8.2 | nM | 380.41 | CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1 | Homo sapiens | CHEMBL3855324 | cell-based format |
| CHEMBL4203847 |  |
IC50 | = | 8.4 | nM | 381.39 | Cn1ncc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL4209481 |  |
IC50 | = | 8.6 | nM | 382.37 | Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc21 | Homo sapiens | CHEMBL4181720 | cell-based format |
| CHEMBL3906199 |  |
IC50 | = | 9.0 | nM | 435.52 | C[C@@H]1CN(Cc2cccc(F)c2F)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 | Homo sapiens | CHEMBL3865204 | cell-based format |