O94966 | UBP19_HUMAN | Ubiquitin carboxyl-terminal hydrolase 19 (USP19)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00443 | UCH | 497–790 | |
| PF00443 | UCH | 834–1211 | |
| PF01753 | zf-MYND | 791–833 | |
| PF04969 | CS | 119–191 | |
| PF04969 | CS | 288–374 | |
| PF16602 | USP19_linker | 375–495 |
3D structures mapped by conservation among orthologs
[ Domain: "HSP20-like chaperones" // CS ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5428753 |  |
IC50 | = | 49.0 | nM | 478.68 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2CC(c3ccccc3)=CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5429248 |  |
IC50 | = | 58.0 | nM | 507.72 | CC(CC1CCCCC1)C(=O)N1CCC(CN2Cc3c(C(=O)N(C)C)cccc3C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5396358 |  |
IC50 | = | 74.0 | nM | 466.67 | Cc1ccc2c(c1)CN(C[C@]1(O)CCN(C(=O)[C@H](C)CC3CCCCC3)CC13CCCC3)C2=O | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5433263 |  |
IC50 | = | 110.0 | nM | 480.69 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2C[C@H](c3ccccc3)CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5396766 |  |
IC50 | = | 110.0 | nM | 515.14 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2C[C@@H](c3ccc(Cl)cc3)CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5417864 |  |
IC50 | = | 120.0 | nM | 510.72 | COc1cccc([C@H]2CC(=O)N(C[C@]3(O)CCN(C(=O)[C@H](C)CC4CCCCC4)CC34CCCC4)C2)c1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5432985 |  |
IC50 | = | 140.0 | nM | 480.69 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2C[C@@H](c3ccccc3)CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5428250 |  |
IC50 | = | 150.0 | nM | 494.72 | Cc1ccccc1[C@@H]1CC(=O)N(C[C@]2(O)CCN(C(=O)[C@H](C)CC3CCCCC3)CC23CCCC3)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5439024 |  |
IC50 | = | 150.0 | nM | 523.72 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2Cc3c(C(=O)N(C)C)cccc3C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5439171 |  |
IC50 | = | 190.0 | nM | 523.72 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2Cc3cc(C(=O)N(C)C)ccc3C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5431080 |  |
IC50 | = | 210.0 | nM | 510.72 | COc1cccc([C@@H]2CC(=O)N(C[C@]3(O)CCN(C(=O)[C@H](C)CC4CCCCC4)CC34CCCC4)C2)c1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5403806 |  |
IC50 | = | 220.0 | nM | 494.72 | Cc1ccc([C@H]2CC(=O)N(C[C@]3(O)CCN(C(=O)[C@H](C)CC4CCCCC4)CC34CCCC4)C2)cc1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5400910 |  |
IC50 | = | 280.0 | nM | 518.7 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2Cc3c(cccc3-n3cccn3)C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5429133 |  |
IC50 | = | 280.0 | nM | 519.69 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2Cc3c(cccc3-c3ncco3)C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5437136 |  |
IC50 | = | 290.0 | nM | 515.14 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2C[C@H](c3ccc(Cl)cc3)CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5421217 |  |
IC50 | = | 320.0 | nM | 494.72 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2C[C@@](C)(c3ccccc3)CC2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5412764 |  |
IC50 | = | 440.0 | nM | 487.08 | C[C@H](CC1CCCCC1)C(=O)N1CC[C@@](O)(CN2Cc3c(Cl)cccc3C2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5403412 |  |
IC50 | = | 450.0 | nM | 494.72 | Cc1ccc([C@@H]2CC(=O)N(C[C@]3(O)CCN(C(=O)[C@H](C)CC4CCCCC4)CC34CCCC4)C2)cc1 | Homo sapiens | CHEMBL5393570 | single protein format |
| CHEMBL5083760 |  |
IC50 | < | 500.0 | nM | 501.62 | C[C@H](CC1CCCCC1)C(=O)N1CCC(O)(Cn2cnc3cc(F)c(F)cc3c2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5053341 | single protein format |
| CHEMBL5082308 |  |
IC50 | < | 500.0 | nM | 483.63 | C[C@H](CC1CCCCC1)C(=O)N1CCC(O)(Cn2cnc3ccc(F)cc3c2=O)C2(CCCC2)C1 | Homo sapiens | CHEMBL5053341 | single protein format |