O94953 | KDM4B_HUMAN | Lysine-specific demethylase 4B (KDM4B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02373 | JmjC - JmjC domain, hydroxylase | 176~292 | |
| PF02375 | JmjN - jmjN domain | 16~50 | |
| PF13831 | PHD_2 - PHD-finger | 754~789 | |
| PF13832 | zf-HC5HC2H_2 - PHD-zinc-finger like domain | 796~906 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 922~956 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 980~1014 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // LBR_tudor_1 ]
[ Domain: "Double-stranded beta-helix" // JmjC ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3785491 |  |
IC50 | = | 10.0 | nM | 382.46 | O=C(NCCCc1ccccc1)c1cccc(-c2cc(O)c3ncccc3c2)c1 | Homo sapiens | CHEMBL3791427 | cell-based format |
| CHEMBL4438830 |  |
IC50 | = | 12.0 | nM | 471.61 | CN(C)CCc1cccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)c1 | Homo sapiens | CHEMBL4353711 | single protein format |
| CHEMBL4440395 |  |
IC50 | = | 15.0 | nM | 513.65 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CCN6CCOCC6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL3775894 |  |
IC50 | = | 17.0 | nM | 469.38 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(Cl)cc(Cl)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778806 | cell-based format |
| CHEMBL4466130 |  |
IC50 | = | 18.0 | nM | 513.65 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(CCN6CCOCC6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4592908 |  |
IC50 | = | 19.0 | nM | 483.62 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CN6CCCC6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4585876 |  |
IC50 | = | 20.0 | nM | 471.61 | CN(C)CCc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4590283 |  |
IC50 | = | 20.0 | nM | 477.57 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6ccncc6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4559561 |  |
IC50 | = | 24.0 | nM | 477.57 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6cccnc6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4567766 |  |
IC50 | = | 27.0 | nM | 477.57 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6cccnc6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL3775668 |  |
IC50 | = | 29.0 | nM | 406.52 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccs5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778806 | cell-based format |
| CHEMBL4573390 |  |
IC50 | = | 29.0 | nM | 448.96 | CC1(c2cccc(Cl)c2)CCN(CCc2cnn(-c3nccc4c(=O)[nH]cnc34)c2)CC1 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL3774537 |  |
IC50 | = | 31.0 | nM | 434.93 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(Cl)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778806 | cell-based format |
| CHEMBL4438034 |  |
IC50 | = | 32.0 | nM | 478.56 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6cncnc6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4447515 |  |
IC50 | = | 32.0 | nM | 418.48 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(F)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4516101 |  |
IC50 | = | 33.0 | nM | 551.62 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(CN6CCCC6)cc(C(F)(F)F)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL4561958 |  |
IC50 | = | 33.0 | nM | 477.57 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6ccccn6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353689 | cell-based format |
| CHEMBL3775121 |  |
IC50 | = | 36.0 | nM | 436.47 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(F)cc5F)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778806 | cell-based format |
| CHEMBL3775548 |  |
IC50 | = | 39.0 | nM | 468.48 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(C(F)(F)F)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778806 | cell-based format |
| CHEMBL3775545 |  |
IC50 | = | 39.0 | nM | 430.51 | COc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL3778806 | cell-based format |