O94806 | KPCD3_HUMAN | Serine/threonine-protein kinase D3 (PRKD3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 580~832 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 155~205 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 272~321 | |
| PF00169 | PH - PH domain | 418~493 | |
| PF25525 | Ubiquitin_PRKD1_N - Serine/threonine-protein kinase D1-like, ubiquitin-like domain | 60~143 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // PH ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5440043 |  |
IC50 | = | 1.0 | nM | 366.47 | NC(=O)c1cc(-c2ccnc(N3CCCCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL5419827 |  |
IC50 | = | 1.5 | nM | 454.57 | CCOc1ccc2cc(-c3cc(-c4cccc(C(=O)NCCN(C)C)c4)cnc3N)ccc2c1 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 1.52 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328570 | single protein format |
| CHEMBL5428541 |  |
IC50 | = | 2.0 | nM | 338.42 | CC[C@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL565612 |  |
IC50 | = | 2.1 | nM | 438.49 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 | Homo sapiens | CHEMBL5159018 | single protein format |
| CHEMBL4515390 |  |
IC50 | = | 6.0 | nM | 338.42 | CC[C@@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL4787572 |  |
IC50 | = | 17.0 | nM | 347.43 | Nc1ncnc2c1c(-c1c[nH]c3ccccc13)nn2CC1CCNCC1 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL1683440 |  |
IC50 | = | 17.0 | nM | 430.51 | C[C@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 | Homo sapiens | CHEMBL1686347 | single protein format |
| CHEMBL4576165 |  |
IC50 | = | 43.0 | nM | 417.52 | CCOc1ccc2cc(-c3nn(CC4CCN(C)CC4)c4ncnc(N)c34)ccc2n1 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL1672571 |  |
IC50 | = | 53.0 | nM | 251.33 | O=C1NCCSc2c1sc1ccc(O)cc21 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL4790321 |  |
IC50 | = | 76.0 | nM | 336.4 | CC(C)(CO)Cn1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL4776166 |  |
IC50 | = | 78.0 | nM | 358.45 | Nc1ncnc2c1c(-c1cccc3ccccc13)nn2CC1CCNCC1 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL264406 |  |
IC50 | = | 104.0 | nM | 317.4 | CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL238125 |  |
IC50 | = | 105.0 | nM | 352.76 | Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1 | Homo sapiens | CHEMBL5316852 | single protein format |
| CHEMBL4779081 |  |
IC50 | = | 108.0 | nM | 306.37 | CC(C)(C)n1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL1933288 |  |
IC50 | = | 219.0 | nM | 458.57 | C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL1937078 | single protein format |
| CHEMBL4536241 |  |
IC50 | = | 280.0 | nM | 390.45 | CC(C)(O)Cn1nc(-c2ccc3nc(OC4CC4)ccc3c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4431820 | single protein format |
| CHEMBL4778331 |  |
IC50 | = | 456.0 | nM | 307.36 | CC(C)(C)n1nc(-c2c[nH]c3cccnc23)c2c(N)ncnc21 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL573578 |  |
IC50 | = | 616.0 | nM | 331.42 | CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 | Homo sapiens | CHEMBL4774311 | cell-based format |
| CHEMBL5393904 |  |
IC50 | = | 624.1 | nM | 542.85 | O=C(c1cccc(CNc2n[nH]c3cccc(Cl)c23)c1)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1 | Homo sapiens | CHEMBL5318992 | single protein format |