O94804 | STK10_HUMAN | Serine/threonine-protein kinase 10 (STK10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 37~294 | |
| PF12474 | PKK - Polo kinase kinase | 587~725 | |
| PF12474 | PKK - Polo kinase kinase | 755~895 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 9.01 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328475 | single protein format |
| CHEMBL156277 |  |
IC50 | = | 12.0 | nM | 328.76 | COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839430 | cell-based format |
| CHEMBL4875188 |  |
IC50 | = | 23.0 | nM | 319.32 | COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839430 | cell-based format |
| CHEMBL288441 |  |
IC50 | = | 52.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244340 | single protein format |
| CHEMBL4878325 |  |
IC50 | = | 60.0 | nM | 398.22 | COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839430 | cell-based format |
| CHEMBL4856751 |  |
IC50 | = | 99.0 | nM | 398.22 | COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839430 | cell-based format |
| CHEMBL6291 |  |
IC50 | = | 99.0 | nM | 457.56 | Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL4839430 | cell-based format |
| CHEMBL103667 |  |
IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602933 | single protein format |
| CHEMBL4875188 | |
Ki | = | 26.0 | nM | 319.32 | COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4878325 | |
Ki | = | 35.0 | nM | 398.22 | COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL156277 | |
Ki | = | 46.0 | nM | 328.76 | COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4877889 |  |
Ki | = | 47.0 | nM | 344.37 | COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4856751 | |
Ki | = | 61.0 | nM | 398.22 | COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL157089 |  |
Ki | = | 73.0 | nM | 344.75 | COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4855513 |  |
Ki | = | 76.0 | nM | 312.3 | COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4869745 |  |
Ki | = | 84.0 | nM | 338.32 | COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4867952 |  |
Ki | = | 88.0 | nM | 404.43 | COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4857159 |  |
Ki | = | 110.0 | nM | 340.4 | COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4868821 |  |
Ki | = | 110.0 | nM | 345.36 | COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839427 | single protein format |
| CHEMBL4877101 |  |
Ki | = | 110.0 | nM | 339.35 | N#Cc1cccc(NC2=C(c3cccc4ccccc34)C(=O)NC2=O)c1 | Homo sapiens | CHEMBL4839427 | single protein format |