O94788 | AL1A2_HUMAN | Retinal dehydrogenase 2 (ALDH1A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00171 | Aldedh - Aldehyde dehydrogenase family | 46~509 |
3D structures mapped by conservation among orthologs
[ Domain: "ALDH-like" // Aldedh_2nd ]
[ Domain: "ALDH-like" // Aldedh_1st_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4849586 |  |
IC50 | = | 21.0 | nM | 405.48 | CC(Sc1nc2nn(C3COC3)cc2c(=O)n1-c1ccccc1)c1ccccn1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4876602 |  |
IC50 | = | 40.0 | nM | 362.46 | C[C@@H](Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4846203 |  |
IC50 | = | 58.0 | nM | 405.48 | CC(Sc1nc2nn(C3COC3)cc2c(=O)n1-c1ccccc1)c1cccnc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4875157 |  |
IC50 | = | 63.0 | nM | 363.45 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccn1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4090473 |  |
IC50 | = | 65.0 | nM | 268.31 | Cc1oc2cc3oc(=O)c4c(c3cc2c1C)CCCC4 | Homo sapiens | CHEMBL4009339 | assay format |
| CHEMBL4847114 |  |
IC50 | = | 65.0 | nM | 404.5 | CC(Sc1nc2nn(C3COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL1562069 |  |
IC50 | = | 69.0 | nM | 256.3 | CCCc1cc(=O)oc2cc3oc(C)c(C)c3cc12 | Homo sapiens | CHEMBL4009339 | assay format |
| CHEMBL4859904 |  |
IC50 | = | 80.0 | nM | 418.52 | CC(Sc1nc2nn(CC3COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4855442 |  |
IC50 | = | 89.0 | nM | 363.45 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccnc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL5269320 |  |
IC50 | = | 100.0 | nM | 354.43 | O=C1CCc2cc(OCCN3CCC[C@@H]3c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226248 | single protein format |
| CHEMBL5283146 |  |
IC50 | = | 100.0 | nM | 354.43 | O=C1CCc2cc(OCCN3CCCC3c3cccc(F)c3)ccc2N1 | Homo sapiens | CHEMBL5226248 | single protein format |
| CHEMBL4848831 |  |
IC50 | = | 100.0 | nM | 378.46 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccc(O)c1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4846491 |  |
IC50 | = | 108.0 | nM | 392.48 | COc1cccc(C(C)Sc2nc3c(cnn3C)c(=O)n2-c2ccccc2)c1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4862833 |  |
IC50 | = | 110.0 | nM | 380.45 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1cccc(F)c1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4848258 |  |
IC50 | = | 110.0 | nM | 362.46 | CC(Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4861872 |  |
IC50 | = | 112.0 | nM | 418.52 | CC(Sc1nc2nn(C3(C)COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL1349972 |  |
IC50 | = | 130.0 | nM | 254.28 | Cc1oc2cc3oc(=O)c4c(c3cc2c1C)CCC4 | Homo sapiens | CHEMBL4009339 | assay format |
| CHEMBL4874309 |  |
IC50 | = | 136.0 | nM | 392.48 | COc1ccccc1C(C)Sc1nc2c(cnn2C)c(=O)n1-c1ccccc1 | Homo sapiens | CHEMBL4811565 | single protein format |
| CHEMBL4213331 |  |
IC50 | = | 150.0 | nM | 366.42 | Cn1ncc2c(=O)n(-c3ccccc3)c(SCc3cccc(F)c3)nc21 | Homo sapiens | CHEMBL4202008 | single protein format |
| CHEMBL4873090 |  |
IC50 | = | 170.0 | nM | 373.44 | Cn1ncc2c(=O)n(-c3ccccc3)c3c(c21)C(=O)C(c1ccccc1)S3 | Homo sapiens | CHEMBL4811565 | single protein format |