O94768 | ST17B_HUMAN | Serine/threonine-protein kinase 17B (STK17B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 36~293 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3797480 |  |
IC50 | = | 3.0 | nM | 376.42 | CCCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL4796519 |  |
IC50 | = | 7.0 | nM | 364.47 | C[S+]([O-])c1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL3799389 |  |
IC50 | = | 8.0 | nM | 360.37 | O=C1Nc2ccc(NC(=O)C3CC3)cc2/C1=C1/Nc2ccccc2/C1=N\O | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL5433785 |  |
IC50 | = | 10.0 | nM | 414.49 | COc1cnc(Nc2ccc(CS(C)(=O)=O)cc2)nc1Nc1cc(C2CC2)[nH]n1 | Homo sapiens | CHEMBL5318944 | single protein format |
| CHEMBL3799585 |  |
IC50 | = | 10.0 | nM | 362.39 | CCCC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL4760126 |  |
IC50 | = | 13.0 | nM | 344.42 | CC(=O)c1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL4753926 |  |
IC50 | = | 14.0 | nM | 387.49 | O=C(O)CSc1ncnc2cc(-c3ccc(N4CCOCC4)cc3)sc12 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL3799505 |  |
IC50 | = | 14.0 | nM | 390.44 | CC(C)(C)CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL3797466 |  |
IC50 | = | 14.0 | nM | 374.4 | CC(C)=CC(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL4763132 |  |
IC50 | = | 18.0 | nM | 350.4 | COc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1F | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL1836719 |  |
IC50 | = | 20.0 | nM | 348.47 | CSc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL513703 |  |
IC50 | = | 21.0 | nM | 376.42 | CC(C)(C)C(=O)Nc1ccc2c(c1)/C(=C1/Nc3ccccc3/C1=N\O)C(=O)N2 | Homo sapiens | CHEMBL3802094 | single protein format |
| CHEMBL1836724 |  |
IC50 | = | 23.0 | nM | 359.43 | CC(=O)Nc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL388978 |  |
IC50 | = | 25.8 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3398958 | single protein format |
| CHEMBL4754748 |  |
IC50 | = | 27.0 | nM | 366.46 | CSc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1F | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL4794509 |  |
IC50 | = | 28.0 | nM | 328.42 | C=Cc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL4060481 |  |
IC50 | = | 29.0 | nM | 332.44 | Nc1c(-c2n[nH]c(=S)o2)sc2ncc(-c3ccsc3)cc12 | Homo sapiens | CHEMBL4014559 | single protein format |
| CHEMBL4788024 |  |
IC50 | = | 33.0 | nM | 370.38 | O=C(O)CSc1ncnc2cc(-c3ccc(C(F)(F)F)cc3)sc12 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL4752776 |  |
IC50 | = | 34.0 | nM | 358.47 | O=C(O)CSc1ncnc2cc(-c3cc4ccccc4s3)sc12 | Homo sapiens | CHEMBL4723757 | assay format |
| CHEMBL1836717 |  |
IC50 | = | 35.0 | nM | 327.39 | N#Cc1ccc(-c2cc3ncnc(SCC(=O)O)c3s2)cc1 | Homo sapiens | CHEMBL4723757 | assay format |