O76083 | PDE9A_HUMAN | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)

Pfam Domain Table

AccessionDomainRangeColor
PF00233PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase311~539

3D structures mapped by conservation among orthologs

[ Domain: "HD-domain/PDEase-like" // PDEase_I ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3360415 IC50 = 0.6 nM 396.45 COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 Homo sapiens CHEMBL3383761 single protein format
CHEMBL2179099 IC50 = 0.9 nM 411.48 C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 Homo sapiens CHEMBL2185813 cell-based format
CHEMBL2179093 IC50 = 1.0 nM 310.36 O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCOCC1 Homo sapiens CHEMBL2185813 cell-based format
CHEMBL3360419 IC50 = 1.05 nM 370.41 COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C(C)C)c(=O)[nH]2)cc1 Homo sapiens CHEMBL3383761 single protein format
CHEMBL3360421 IC50 = 1.1 nM 384.42 C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc(F)cc1 Homo sapiens CHEMBL3383761 single protein format
CHEMBL3676170 IC50 = 1.2 nM 368.44 COc1cc2c(cc1C(=O)N(C)C)[nH]c(=O)c1cnc(C3CCCCC3)n12 Homo sapiens CHEMBL3706015 single protein format
CHEMBL2177125 IC50 = 1.2 nM 411.48 C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 Homo sapiens CHEMBL2185813 cell-based format
CHEMBL2179096 IC50 = 1.7 nM 407.52 CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 Homo sapiens CHEMBL2185813 cell-based format
CHEMBL583914 IC50 = 1.8 nM 429.53 C[C@@H]1CN(Cc2ccc3nccnc3c2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 Homo sapiens CHEMBL1047621 cell-based format
CHEMBL4638644 IC50 = 1.8 nM 406.45 C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]ncc2c1 Homo sapiens CHEMBL4624669 single protein format
CHEMBL565667 IC50 = 1.9 nM 429.53 C[C@H]1CN(Cc2ccc3nccnc3c2)C[C@@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 Homo sapiens CHEMBL1047621 cell-based format
CHEMBL3676175 IC50 = 2.0 nM 285.3 CCc1ccc2c(c1)[nH]c(=O)c1cnc(CCC(=O)O)n12 Homo sapiens CHEMBL3706015 single protein format
CHEMBL4642683 IC50 = 2.0 nM 406.45 C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]cnc2c1 Homo sapiens CHEMBL4624669 single protein format
CHEMBL3693832 IC50 = 2.0 nM 408.44 Cn1cc(-c2ccc(F)cc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 Homo sapiens CHEMBL3706026 single protein format
CHEMBL3676176 IC50 = 2.0 nM 325.25 O=C(O)CCc1ncc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12 Homo sapiens CHEMBL3706015 single protein format
CHEMBL572934 IC50 = 2.1 nM 294.36 O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCCC1 Homo sapiens CHEMBL1047621 cell-based format
CHEMBL4640285 IC50 = 2.1 nM 406.45 C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2nccn2c1 Homo sapiens CHEMBL4624669 single protein format
CHEMBL3938847 IC50 = 2.24 nM 430.51 C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccc3ccccc3n2)C1 Homo sapiens CHEMBL3879918 single protein format
CHEMBL4249954 IC50 = 2.8 nM 429.53 CC1CN(Cc2ccc3nccnc3c2)CC1c1nc(O)c2cnn(C3CCCC3)c2n1 Homo sapiens CHEMBL4231523 cell-based format
CHEMBL3360416 IC50 = 3.0 nM 396.45 COc1ccc(NC(=O)[C@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 Homo sapiens CHEMBL3383761 single protein format