O76083 | PDE9A_HUMAN | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 311~539 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL3360415 | IC50 | = | 0.6 | nM | 396.45 | COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 | Homo sapiens | CHEMBL3383761 | single protein format | |
CHEMBL2179099 | IC50 | = | 0.9 | nM | 411.48 | C[C@@H]1CN(Cc2ccc(F)cc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL2185813 | cell-based format | |
CHEMBL2179093 | IC50 | = | 1.0 | nM | 310.36 | O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCOCC1 | Homo sapiens | CHEMBL2185813 | cell-based format | |
CHEMBL3360419 | IC50 | = | 1.05 | nM | 370.41 | COc1ccc(NC(=O)[C@@H](C)Nc2nc3c(cnn3C(C)C)c(=O)[nH]2)cc1 | Homo sapiens | CHEMBL3383761 | single protein format | |
CHEMBL3360421 | IC50 | = | 1.1 | nM | 384.42 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc(F)cc1 | Homo sapiens | CHEMBL3383761 | single protein format | |
CHEMBL3676170 | IC50 | = | 1.2 | nM | 368.44 | COc1cc2c(cc1C(=O)N(C)C)[nH]c(=O)c1cnc(C3CCCCC3)n12 | Homo sapiens | CHEMBL3706015 | single protein format | |
CHEMBL2177125 | IC50 | = | 1.2 | nM | 411.48 | C[C@@H]1CN(Cc2cccc(F)c2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL2185813 | cell-based format | |
CHEMBL2179096 | IC50 | = | 1.7 | nM | 407.52 | CC[C@@H]1CN(Cc2ccccc2)C[C@H]1c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL2185813 | cell-based format | |
CHEMBL583914 | IC50 | = | 1.8 | nM | 429.53 | C[C@@H]1CN(Cc2ccc3nccnc3c2)C[C@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL1047621 | cell-based format | |
CHEMBL4638644 | IC50 | = | 1.8 | nM | 406.45 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]ncc2c1 | Homo sapiens | CHEMBL4624669 | single protein format | |
CHEMBL565667 | IC50 | = | 1.9 | nM | 429.53 | C[C@H]1CN(Cc2ccc3nccnc3c2)C[C@@H]1c1nc2c(cnn2C2CCCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL1047621 | cell-based format | |
CHEMBL3676175 | IC50 | = | 2.0 | nM | 285.3 | CCc1ccc2c(c1)[nH]c(=O)c1cnc(CCC(=O)O)n12 | Homo sapiens | CHEMBL3706015 | single protein format | |
CHEMBL4642683 | IC50 | = | 2.0 | nM | 406.45 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2[nH]cnc2c1 | Homo sapiens | CHEMBL4624669 | single protein format | |
CHEMBL3693832 | IC50 | = | 2.0 | nM | 408.44 | Cn1cc(-c2ccc(F)cc2Cc2nc3c(cnn3C3CCOCC3)c(=O)[nH]2)cn1 | Homo sapiens | CHEMBL3706026 | single protein format | |
CHEMBL3676176 | IC50 | = | 2.0 | nM | 325.25 | O=C(O)CCc1ncc2c(=O)[nH]c3cc(C(F)(F)F)ccc3n12 | Homo sapiens | CHEMBL3706015 | single protein format | |
CHEMBL572934 | IC50 | = | 2.1 | nM | 294.36 | O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCCC1 | Homo sapiens | CHEMBL1047621 | cell-based format | |
CHEMBL4640285 | IC50 | = | 2.1 | nM | 406.45 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)[nH]1)C(=O)Nc1ccc2nccn2c1 | Homo sapiens | CHEMBL4624669 | single protein format | |
CHEMBL3938847 | IC50 | = | 2.24 | nM | 430.51 | C[C@H](c1nc2c(cnn2C2CCOCC2)c(=O)[nH]1)N1CC(c2ccc3ccccc3n2)C1 | Homo sapiens | CHEMBL3879918 | single protein format | |
CHEMBL4249954 | IC50 | = | 2.8 | nM | 429.53 | CC1CN(Cc2ccc3nccnc3c2)CC1c1nc(O)c2cnn(C3CCCC3)c2n1 | Homo sapiens | CHEMBL4231523 | cell-based format | |
CHEMBL3360416 | IC50 | = | 3.0 | nM | 396.45 | COc1ccc(NC(=O)[C@H](C)Nc2nc3c(cnn3C3CCCC3)c(=O)[nH]2)cc1 | Homo sapiens | CHEMBL3383761 | single protein format |