O76074 | PDE5A_HUMAN | cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 612~845 | |
| PF01590 | GAF - GAF domain | 164~312 | |
| PF01590 | GAF - GAF domain | 347~501 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Domain: "sensor domains" // GAF ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1094489 |  |
IC50 | = | 0.007 | nM | 438.58 | CCOCCn1nc(CC)c2nc(N3CCC(CN)CC3)nc(Nc3cc(C)ccn3)c21 | Homo sapiens | CHEMBL1106526 | assay format |
| CHEMBL1916488 |  |
IC50 | = | 0.01 | nM | 468.51 | CCCOCCn1c(=O)nc(N2CCC(C(=O)O)CC2)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1916483 |  |
IC50 | = | 0.01 | nM | 482.54 | CCCOCCn1c(=O)nc(NC2CCCC(C(=O)O)C2)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1098465 |  |
IC50 | = | 0.011 | nM | 438.58 | CCOCCn1nc(CC)c2nc(NCC3CCNCC3)nc(Nc3cc(C)ccn3)c21 | Homo sapiens | CHEMBL1106526 | assay format |
| CHEMBL1916485 |  |
IC50 | = | 0.02 | nM | 482.54 | CCCOCCn1c(=O)nc(N[C@@H]2CCCC[C@@H]2C(=O)O)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1916486 |  |
IC50 | = | 0.02 | nM | 482.54 | CCCOCCn1c(=O)nc(NC2CCC(C(=O)O)CC2)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1916475 |  |
IC50 | = | 0.02 | nM | 454.53 | CCCOCCn1c(=O)nc(NC2CCC(O)CC2)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL4759667 |  |
IC50 | = | 0.025 | nM | 508.63 | CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCS(=N)(=O)CC4)ccc3OCC)nn12 | Homo sapiens | CHEMBL4709736 | cell-based format |
| CHEMBL3654363 |  |
IC50 | = | 0.028 | nM | 465.94 | COc1ccc(COc2nc(N3CC4CC4C3)ncc2C(=O)NCc2ccccn2)cc1Cl | Homo sapiens | CHEMBL3706232 | single protein format |
| CHEMBL410215 |  |
IC50 | = | 0.03 | nM | 495.97 | CCn1ncc2c3c(NCc4ccc(OC)c(Cl)c4)nnc(N4CCC(C(=O)O)CC4)c3cnc21 | Homo sapiens | CHEMBL762826 | assay format |
| CHEMBL1094365 |  |
IC50 | = | 0.04 | nM | 453.55 | CCOCCn1nc(CC)c2nc(N3CCC(C(=O)O)CC3)nc(Nc3cc(C)ccn3)c21 | Homo sapiens | CHEMBL1106526 | assay format |
| CHEMBL569481 |  |
IC50 | = | 0.04 | nM | 446.51 | CCCOCCn1c(=O)c(NCc2ccccn2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042744 | single protein format |
| CHEMBL1916476 |  |
IC50 | = | 0.04 | nM | 494.47 | COc1ccc(-c2cc3c(nn2)c(NC2CCC(O)CC2)nc(=O)n3CCOCC(F)(F)F)cn1 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1916487 |  |
IC50 | = | 0.04 | nM | 482.54 | CCCOCCn1c(=O)nc(N2CCC(CC(=O)O)CC2)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL38735 |  |
IC50 | = | 0.05 | nM | 381.86 | CCc1cc(C#N)cc2c(NCc3ccc(OC)c(Cl)c3)c(CO)cnc12 | Homo sapiens | CHEMBL762822 | assay format |
| CHEMBL1916293 |  |
IC50 | = | 0.05 | nM | 453.54 | CCCOCCn1c(=O)nc(NC2CCC(O)CC2)c2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL567470 |  |
IC50 | = | 0.05 | nM | 453.54 | CCCOCCn1c(=O)c(N[C@H]2CC[C@H](O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042744 | single protein format |
| CHEMBL584270 |  |
IC50 | = | 0.05 | nM | 439.52 | CCCOCCn1c(=O)c(NCC2CCCO2)nc2cnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1042744 | single protein format |
| CHEMBL1916303 |  |
IC50 | = | 0.05 | nM | 428.45 | CCCOCCn1c(=O)nc(NCCC(=O)O)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |
| CHEMBL1916482 |  |
IC50 | = | 0.05 | nM | 442.48 | CCCOCCn1c(=O)nc(NC(C)(C)C(=O)O)c2nnc(-c3ccc(OC)nc3)cc21 | Homo sapiens | CHEMBL1919539 | single protein format |