O75907 | DGAT1_HUMAN | Diacylglycerol O-acyltransferase 1 (DGAT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03062 | MBOAT - MBOAT, membrane-bound O-acyltransferase family | 155~474 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2036730 |  |
IC50 | = | 0.6 | nM | 456.45 | O=C(O)C[C@H]1CC[C@H](c2ccc(NC(=O)c3nnc(Nc4ccc(F)c(F)c4)o3)cc2)CC1 | Homo sapiens | CHEMBL2038283 | cell-based format |
| CHEMBL3969207 |  |
IC50 | = | 0.63 | nM | 459.47 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1ccc(-c2ncc(C3(C(F)(F)F)CC3)[nH]2)cc1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL4585408 |  |
IC50 | = | 0.7 | nM | 422.87 | CC(C)(COc1ccc(-c2ccc(-c3nc4cc(Cl)ccc4[nH]3)cn2)cn1)C(=O)O | Homo sapiens | CHEMBL4392490 | single protein format |
| CHEMBL3913687 |  |
IC50 | = | 0.75 | nM | 449.4 | Cc1cc(OCC2(C(=O)O)CCC2)ncc1-c1ccc(-c2nc(C(F)(F)F)c[nH]2)c(F)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3922835 |  |
IC50 | = | 0.76 | nM | 434.42 | CCC(CC)(COc1ccc(-c2ccc(-c3ncc(C(F)(F)F)[nH]3)nc2)cn1)C(=O)O | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3929252 |  |
IC50 | = | 0.78 | nM | 433.43 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1ccc(-c2ncc(C(F)(F)F)[nH]2)c(C)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3921484 |  |
IC50 | = | 0.82 | nM | 465.86 | Cc1cc(OCC2(C(=O)O)CCC2)ncc1-c1ccc(-c2nc(C(F)(F)F)c[nH]2)c(Cl)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3914327 |  |
IC50 | = | 0.87 | nM | 423.37 | CC(C)(COc1ncc(-c2ccc(-c3ncc(C(F)(F)F)[nH]3)cc2)cc1F)C(=O)O | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3907562 |  |
IC50 | = | 0.96 | nM | 437.39 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1ccc(-c2nc(C(F)(F)F)c[nH]2)c(F)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3910570 |  |
IC50 | < | 1.0 | nM | 529.71 | CC(C)(C)c1ccc(CNC(=O)c2cn3cc(-c4ccc([C@H]5CC[C@H](CC(=O)O)CC5)cc4)sc3n2)cc1 | Homo sapiens | CHEMBL3888061 | tissue-based format |
| CHEMBL3898541 |  |
IC50 | = | 1.0 | nM | 504.84 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1cnc(-c2ncc(C(F)(F)C(F)(F)F)[nH]2)c(Cl)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3987192 |  |
IC50 | < | 1.0 | nM | 507.51 | O=C(O)CC1CCC(c2ccc(-c3ccc4nc(C(=O)Nc5cc(F)c(F)c(F)c5)cn4c3)cc2)CC1 | Homo sapiens | CHEMBL3888061 | tissue-based format |
| CHEMBL3931131 |  |
IC50 | < | 1.0 | nM | 467.57 | Cc1ccccc1NC(=O)c1cn2cc(-c3ccc(C4CCC(CC(=O)O)CC4)cc3)ccc2n1 | Homo sapiens | CHEMBL3888061 | tissue-based format |
| CHEMBL3969728 |  |
IC50 | = | 1.2 | nM | 453.85 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1ccc(-c2nc(C(F)(F)F)c[nH]2)c(Cl)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL3966083 |  |
IC50 | = | 1.2 | nM | 405.5 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1ccc(-c2ncc(CC3CC3)[nH]2)cc1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL2408620 |  |
IC50 | = | 1.3 | nM | 450.45 | O=C(O)[C@H]1CC[C@H](Oc2ccc(-c3ccc(-c4nc5cc(F)c(F)cc5[nH]4)cn3)cn2)CC1 | Homo sapiens | CHEMBL2410614 | single protein format |
| CHEMBL3919047 |  |
IC50 | = | 1.3 | nM | 454.84 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1cnc(-c2ncc(C(F)(F)F)[nH]2)c(Cl)c1 | Homo sapiens | CHEMBL3888275 | assay format |
| CHEMBL4453443 |  |
IC50 | = | 1.3 | nM | 462.94 | O=C(O)C[C@H]1CC[C@@H](Oc2ccc(-c3ccc(-c4nc5cc(Cl)ccc5[nH]4)cn3)cn2)CC1 | Homo sapiens | CHEMBL4392490 | single protein format |
| CHEMBL4467163 |  |
IC50 | = | 1.3 | nM | 442.86 | O=C(O)c1ccc(Oc2ccc(-c3ccc(-c4nc5cc(Cl)ccc5[nH]4)cn3)cn2)cc1 | Homo sapiens | CHEMBL4392490 | single protein format |
| CHEMBL3929034 |  |
IC50 | = | 1.4 | nM | 438.38 | Cc1cc(OCC(C)(C)C(=O)O)ncc1-c1cnc(-c2ncc(C(F)(F)F)[nH]2)c(F)c1 | Homo sapiens | CHEMBL3888275 | assay format |