O75762 | TRPA1_HUMAN | Transient receptor potential cation channel subfamily A member 1 (TRPA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 241~266 | |
| PF00023 | Ank - Ankyrin repeat | 412~439 | |
| PF00520 | Ion_trans - Ion transport protein | 745~971 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 61~128 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 131~193 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 276~372 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 450~539 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 544~600 |
3D structures mapped by conservation among orthologs
[ Domain: "Ankyrin repeat" // Ank_2 ]
[ Domain: "Voltage-gated ion channels" // Ion_trans_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4208555 |  |
IC50 | = | 0.7 | nM | 509.01 | O=C(NC[C@@H](Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 | Homo sapiens | CHEMBL4190628 | single protein format |
| CHEMBL5408439 |  |
IC50 | = | 1.0 | nM | 321.37 | C#CC(CC)(CC)NC(=O)c1cccnc1NC1CC(F)(F)C1 | Homo sapiens | CHEMBL5318380 | cell-based format |
| CHEMBL3907685 |  |
IC50 | = | 1.0 | nM | 509.01 | O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CCCC1 | Homo sapiens | CHEMBL3858029 | cell-based format |
| CHEMBL4849329 |  |
IC50 | = | 1.2 | nM | 412.84 | Cn1cnc2ncn(Cc3nc([C@@H]4CO[C@@H](c5ccc(Cl)cc5)C4)no3)c(=O)c21 | Homo sapiens | CHEMBL4828020 | cell-based format |
| CHEMBL3976535 |  |
IC50 | = | 1.45 | nM | 563.34 | Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(Cl)c(OCC(F)(F)F)c(Cl)c4)cs3)coc2n(C)c1=O | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3974013 |  |
IC50 | = | 1.68 | nM | 544.46 | Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3903533 |  |
IC50 | = | 2.0 | nM | 498.95 | O=C(NCC(Cc1ccc(F)cc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL3858029 | cell-based format |
| CHEMBL3947821 |  |
IC50 | = | 2.15 | nM | 482.42 | Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)cc(C(F)(F)F)c4)cs3)coc2n(C)c1=O | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3976217 |  |
IC50 | = | 2.21 | nM | 482.42 | Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cccc(C(F)(F)F)c4F)cs3)coc2n(C)c1=O | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL4870870 |  |
IC50 | = | 2.9 | nM | 423.86 | Cn1cnc2ncn(Cc3nc([C@H]4[C@@H]5CN(c6cccc(Cl)c6)C[C@@H]54)no3)c(=O)c21 | Homo sapiens | CHEMBL4828020 | cell-based format |
| CHEMBL3905460 |  |
IC50 | = | 2.93 | nM | 496.44 | Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)cc(C(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3927494 |  |
IC50 | = | 3.18 | nM | 512.9 | Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(Cl)c(C(F)(F)F)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3920312 |  |
IC50 | = | 3.34 | nM | 551.45 | Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(Cl)c(OCC(C)C)c(Cl)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3981050 |  |
IC50 | = | 3.38 | nM | 528.46 | Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(CCC(F)(F)F)c(F)c4)cs3)coc2n(C)c1=O | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3929233 |  |
IC50 | = | 3.54 | nM | 546.89 | Cn1c(=O)c2c(CC(=O)Nc3nc(-c4cc(F)c(OCC(F)(F)F)c(Cl)c4)cs3)coc2n(C)c1=O | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3904770 |  |
IC50 | = | 3.63 | nM | 532.57 | Cc1oc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(C)(C)C)c(F)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL3896353 |  |
IC50 | = | 3.98 | nM | 574.55 | CCc1sc2c(c1CC(=O)Nc1nc(-c3cc(F)c(OCC(F)(F)F)c(F)c3)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |
| CHEMBL5428371 |  |
IC50 | = | 4.0 | nM | 276.27 | O[C@@]1(C(F)(F)F)CCCC[C@@H]1Cc1ccc(F)cc1 | Homo sapiens | CHEMBL5318377 | cell-based format |
| CHEMBL3982480 |  |
IC50 | = | 4.0 | nM | 506.58 | O=C(NCC(Cc1ccccc1)N1CCC(O)(C(F)(F)F)CC1)C1(c2ccc(F)cc2)CCCCC1 | Homo sapiens | CHEMBL3858029 | cell-based format |
| CHEMBL3898239 |  |
IC50 | = | 4.02 | nM | 514.43 | Cc1oc2c(c1CC(=O)Nc1nc(-c3ccc(C(F)(F)F)c(F)c3F)cs1)c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3887573 | cell-based format |