O75716 | STK16_HUMAN | Serine/threonine-protein kinase 16 (STK16)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 22~287 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5079149 |  |
IC50 | = | 82.0 | nM | 546.45 | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 | Homo sapiens | CHEMBL5046583 | single protein format |
| CHEMBL5083125 |  |
IC50 | = | 88.0 | nM | 533.45 | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1 | Homo sapiens | CHEMBL5046583 | single protein format |
| CHEMBL4877883 |  |
IC50 | = | 107.0 | nM | 435.92 | Cn1ncc2cc(-c3cnc4[nH]nc(Cl)c4c3N3CCC4(CCNC4=O)CC3)ccc21 | Homo sapiens | CHEMBL4828668 | assay format |
| CHEMBL5437375 |  |
IC50 | = | 148.0 | nM | 517.6 | Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1-c1nc2c(C(N)=O)cccc2[nH]1 | Homo sapiens | CHEMBL5324552 | single protein format |
| CHEMBL187139 |  |
IC50 | = | 167.0 | nM | 416.36 | COc1cc(Nc2nccc(-c3cnn4nc(OC)ccc34)n2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL5213629 | assay format |
| CHEMBL388978 |  |
IC50 | = | 235.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328613 | single protein format |
| CHEMBL5174830 |  |
IC50 | = | 560.0 | nM | 331.42 | CN(C)CC#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5479583 | single protein format |
| CHEMBL4069365 |  |
IC50 | = | 885.0 | nM | 421.38 | CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21 | Homo sapiens | CHEMBL4007747 | single protein format |
| CHEMBL4571548 |  |
Ki | = | 78.0 | nM | 412.52 | CC(C)CS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4470026 |  |
Ki | = | 86.0 | nM | 427.53 | CCN(C)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4534959 |  |
Ki | = | 91.0 | nM | 410.5 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4552310 |  |
Ki | = | 110.0 | nM | 398.49 | CCCS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4542463 |  |
Ki | = | 150.0 | nM | 424.53 | O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4582326 |  |
Ki | = | 180.0 | nM | 452.46 | O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CC(F)(F)F)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4447403 |  |
Ki | = | 180.0 | nM | 466.49 | O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CCC(F)(F)F)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4472438 |  |
Ki | = | 220.0 | nM | 441.56 | CCN(CC)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4535040 |  |
Ki | = | 240.0 | nM | 410.5 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CCC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4452939 |  |
Ki | = | 270.0 | nM | 427.53 | CCN(CC)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4561238 |  |
Ki | = | 290.0 | nM | 481.5 | CN(CC(F)(F)F)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |
| CHEMBL4531680 |  |
Ki | = | 310.0 | nM | 413.5 | CCN(C)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345186 | assay format |