O75676 | KS6A4_HUMAN | Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 33~301 | |
| PF00069 | Pkinase - Protein kinase domain | 416~673 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 322~361 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL495727 |  |
IC50 | = | 10.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL1009917 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 11.3 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328511 | single protein format |
| CHEMBL248757 |  |
Ki | = | 949.0 | nM | 471.93 | N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 | Homo sapiens | CHEMBL942722 | single protein format |