O75643 | U520_HUMAN | U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00270 | DEAD - DEAD/DEAH box helicase | 482~660 | |
| PF00270 | DEAD - DEAD/DEAH box helicase | 1329~1499 | |
| PF00271 | Helicase_C - Helicase conserved C-terminal domain | 767~859 | |
| PF02889 | Sec63 - Sec63 Brl domain | 982~1285 | |
| PF02889 | Sec63 - Sec63 Brl domain | 1812~2123 | |
| PF18149 | Helicase_PWI - N-terminal helicase PWI domain | 255~363 | |
| PF21188 | BRR2_plug - Pre-mRNA-splicing helicase BRR2 plug domain | 109~175 | |
| PF23445 | SNRNP200_wHTH - Winged Helix-turn-helix domain | 890~966 | |
| PF23445 | SNRNP200_wHTH - Winged Helix-turn-helix domain | 1725~1806 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Sec63_3rd ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD_1,KOG0951_2nd ]
[ Domain: "Pre-mRNA-splicing helicase BRR2 NC-clamp" // KOG0951_2nd ]
[ Domain: "winged" // KOG0952 ]
[ Domain: "SAM-like subdomain in Sec63-like proteins" // Sec63_2nd_1 ]
[ Domain: "SAM-like subdomain in Sec63-like proteins" // Sec63_2nd ]
[ Domain: "Sec63 N-terminal subdomain-like" // Sec63_1st ]
[ Domain: "PWI domain" // KOG0951_1st ]
[ Domain: "Pre-mRNA-splicing helicase BRR2 plug domain" // EUF08005 ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD_1 ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_5 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4091579 |  |
IC50 | = | 24.0 | nM | 460.55 | CC(C)C[C@H]1C[C@@H](C)[C@]2(C(=O)Nc3ccc(F)cc32)N1C(=O)c1cn(Cc2ccccc2)cn1 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4070683 |  |
IC50 | = | 42.0 | nM | 384.45 | CC(C)C[C@H]1C[C@@H](C)[C@]2(C(=O)Nc3ccc(F)cc32)N1C(=O)c1cn(C)cn1 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4104317 |  |
IC50 | = | 44.0 | nM | 504.56 | COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(Cc3ccccc3)cn2)[C@@]12C(=O)Nc1ccc(F)cc12 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4084949 |  |
IC50 | = | 79.0 | nM | 444.52 | O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 | Homo sapiens | CHEMBL4017288 | cell-based format |
| CHEMBL4100976 |  |
IC50 | = | 110.0 | nM | 428.46 | COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(C)cn2)[C@@]12C(=O)Nc1ccc(F)cc12 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4097764 |  |
IC50 | = | 180.0 | nM | 438.49 | O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 | Homo sapiens | CHEMBL4017288 | cell-based format |
| CHEMBL4088975 |  |
IC50 | = | 360.0 | nM | 363.46 | CC(C)C[C@H]1C[C@@H](C)[C@]2(C(=O)Nc3ccccc32)N1C(=O)c1ccccn1 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4080080 |  |
IC50 | = | 390.0 | nM | 414.44 | COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2c[nH]cn2)[C@@]12C(=O)Nc1ccc(F)cc12 | Homo sapiens | CHEMBL4044703 | cell-based format |
| CHEMBL4065018 |  |
IC50 | = | 790.0 | nM | 437.5 | O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 | Homo sapiens | CHEMBL4017288 | cell-based format |
| CHEMBL4076145 |  |
IC50 | = | 910.0 | nM | 425.46 | COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]12C(=O)Nc1ccc(F)cc12 | Homo sapiens | CHEMBL4044703 | cell-based format |