O75582 | KS6A5_HUMAN | Ribosomal protein S6 kinase alpha-5 (RPS6KA5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 49~318 | |
| PF00069 | Pkinase - Protein kinase domain | 429~686 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 339~377 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL188434 |  |
IC50 | = | 0.5 | nM | 342.41 | CCn1c(-c2nonc2N)nc2cncc(CNC3CCNCC3)c21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL521823 |  |
IC50 | = | 1.0 | nM | 343.39 | CCn1c(-c2nonc2N)nc2cncc(OCC3CCNCC3)c21 | Homo sapiens | CHEMBL1028091 | single protein format |
| CHEMBL415770 |  |
IC50 | = | 1.4 | nM | 328.38 | CCn1c(-c2nonc2N)nc2cncc(CN3CCNCC3)c21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 1.4 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3807898 | single protein format |
| CHEMBL185962 |  |
IC50 | = | 1.8 | nM | 242.24 | Nc1nonc1-c1nc2cnccc2n1C1CC1 | Homo sapiens | CHEMBL828472 | single protein format |
| CHEMBL188806 |  |
IC50 | = | 2.0 | nM | 285.31 | Nc1nonc1-c1nc2cnccc2n1C1CCCNC1 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL186317 |  |
IC50 | = | 2.5 | nM | 307.32 | NCc1cccc(-n2c(-c3nonc3N)nc3cnccc32)c1 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL426440 |  |
IC50 | = | 3.0 | nM | 342.41 | CCn1c(-c2nonc2N)nc2cncc(CN3CCC(N)CC3)c21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL189657 |  |
IC50 | = | 3.0 | nM | 230.23 | CCn1c(-c2nonc2N)nc2cnccc21 | Homo sapiens | CHEMBL828472 | single protein format |
| CHEMBL189231 |  |
IC50 | = | 3.0 | nM | 284.32 | Nc1nonc1-c1nc2cnccc2n1C1CCCCC1 | Homo sapiens | CHEMBL828472 | single protein format |
| CHEMBL523695 |  |
IC50 | = | 3.0 | nM | 342.36 | CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@@H](N)C3)c21 | Homo sapiens | CHEMBL1028091 | single protein format |
| CHEMBL2347053 |  |
IC50 | = | 4.0 | nM | 332.32 | O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] | Homo sapiens | CHEMBL2353278 | single protein format |
| CHEMBL188268 |  |
IC50 | = | 4.0 | nM | 307.32 | NCc1ccc(-n2c(-c3nonc3N)nc3cnccc32)cc1 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL187340 |  |
IC50 | = | 4.0 | nM | 264.68 | CCn1c(-c2nonc2N)nc2c(Cl)nccc21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL360219 |  |
IC50 | = | 7.0 | nM | 327.39 | CCn1c(-c2nonc2N)nc2cncc(CN3CCCCC3)c21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL6291 |  |
IC50 | = | 8.0 | nM | 457.56 | Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 | Homo sapiens | CHEMBL1249799 | cell-based format |
| CHEMBL364413 |  |
IC50 | = | 8.0 | nM | 244.26 | CCn1c(-c2nonc2N)nc2c(C)nccc21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL188620 |  |
IC50 | = | 9.0 | nM | 259.27 | CC(CN)n1c(-c2nonc2N)nc2cnccc21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL365832 |  |
IC50 | = | 9.0 | nM | 309.13 | CCn1c(-c2nonc2N)nc2cncc(Br)c21 | Homo sapiens | CHEMBL877123 | single protein format |
| CHEMBL188433 |  |
IC50 | = | 11.0 | nM | 278.28 | Nc1nonc1-c1nc2cnccc2n1-c1ccccc1 | Homo sapiens | CHEMBL828472 | single protein format |