O75530 | EED_HUMAN | Polycomb protein EED (EED)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00400 | WD40 - WD domain, G-beta repeat | 181~219 | |
| PF00400 | WD40 - WD domain, G-beta repeat | 233~263 | |
| PF00400 | WD40 - WD domain, G-beta repeat | 401~438 |
3D structures mapped by conservation among orthologs
[ Domain: "7-bladed" // ANAPC4_WD40_5 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4637096 |  |
IC50 | = | 0.2 | nM | 489.48 | CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)F)nc3)c12 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4637520 |  |
IC50 | = | 0.2 | nM | 479.54 | CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C4CC4)nc3)c12 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4870920 |  |
IC50 | = | 0.2 | nM | 528.51 | CC(C)N1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4638412 |  |
IC50 | = | 0.3 | nM | 507.47 | CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(C(F)(F)F)nc3)c12 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4644746 |  |
IC50 | = | 0.4 | nM | 521.5 | Cc1nc(C(F)(F)F)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnc(S(C)(=O)=O)c12 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4865691 |  |
IC50 | = | 0.4 | nM | 421.44 | Cn1ncc2c1CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4645310 |  |
IC50 | = | 0.4 | nM | 453.5 | Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4645324 |  |
IC50 | = | 0.4 | nM | 516.58 | CS(=O)(=O)c1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cc1 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4643880 |  |
IC50 | = | 0.4 | nM | 456.47 | CS(=O)(=O)c1ncn2c(NCc3c(F)ccc4c3CCO4)ncc(-c3ccc(F)cc3)c12 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4851576 |  |
IC50 | = | 0.5 | nM | 417.44 | O=C1NCc2ccccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4642335 |  |
IC50 | = | 0.5 | nM | 442.48 | Cn1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)cn1 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4635558 |  |
IC50 | = | 0.5 | nM | 467.53 | Cc1ccc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnc(S(C)(=O)=O)c23)c(C)n1 | Homo sapiens | CHEMBL4613059 | single protein format |
| CHEMBL4872891 |  |
IC50 | = | 0.6 | nM | 435.43 | O=C1NCc2cc(F)ccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4869420 |  |
IC50 | = | 0.6 | nM | 500.46 | CN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4877375 |  |
IC50 | = | 0.6 | nM | 514.48 | CCN1Cc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC(C1=O)C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4860499 |  |
IC50 | = | 0.6 | nM | 584.57 | O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1CC1CCOCC1)C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4859559 |  |
IC50 | = | 0.7 | nM | 486.43 | O=C1NCc2cc(C(F)(F)F)ncc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4873268 |  |
IC50 | = | 0.7 | nM | 418.43 | O=C1NCc2ncccc2C2=CN=C(NCc3c(F)ccc4c3CCO4)N3C=NC1C23 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4861749 |  |
IC50 | = | 0.7 | nM | 432.46 | Cc1ccc2c(n1)CNC(=O)C1N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C2C13 | Homo sapiens | CHEMBL4828520 | single protein format |
| CHEMBL4850823 |  |
IC50 | = | 0.7 | nM | 570.55 | O=C1C2N=CN3C(NCc4c(F)ccc5c4CCO5)=NC=C(c4cnc(C(F)(F)F)cc4CN1C1CCOCC1)C23 | Homo sapiens | CHEMBL4828520 | single protein format |