O75469 | NR1I2_HUMAN | Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 242~411 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 40~109 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5286515 |  |
IC50 | = | 1.6 | nM | 480.61 | CCCC(C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239755 | cell-based format |
| CHEMBL410683 |  |
IC50 | = | 2.4 | nM | 312.45 | C/C=C1\C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | Homo sapiens | CHEMBL880930 | single protein format |
| CHEMBL402063 |  |
IC50 | = | 2.4 | nM | 312.45 | C/C=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C | Homo sapiens | CHEMBL880930 | single protein format |
| CHEMBL5277255 |  |
IC50 | = | 4.0 | nM | 464.61 | CCC[C@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(C)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5284539 |  |
IC50 | = | 6.0 | nM | 480.61 | CCC[C@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5285451 |  |
IC50 | = | 7.0 | nM | 485.03 | CCC[C@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(Cl)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5282848 |  |
IC50 | = | 7.0 | nM | 480.61 | CCC(C)COc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5274748 |  |
IC50 | = | 11.0 | nM | 464.61 | CCC[C@@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(C)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5288280 |  |
IC50 | = | 12.0 | nM | 480.61 | COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(C(C)(C)C)ccc3OCCC(C)C)c2C)c1 | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5284102 |  |
IC50 | = | 14.0 | nM | 470.57 | COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(-c4ccccc4)cc(C(C)(C)C)c3)c2C)c1 | Homo sapiens | CHEMBL5239755 | cell-based format |
| CHEMBL5274800 |  |
IC50 | = | 14.0 | nM | 450.58 | CCCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(C)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5277006 |  |
IC50 | = | 15.0 | nM | 485.03 | CCC[C@@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(Cl)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5269977 |  |
IC50 | = | 16.0 | nM | 471.0 | CCCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(Cl)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5290100 |  |
IC50 | = | 16.0 | nM | 471.0 | CCCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2Cl)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5281952 |  |
IC50 | = | 18.0 | nM | 464.61 | CCCC(C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(C)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5289969 |  |
IC50 | = | 20.0 | nM | 485.03 | CCCC(C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(Cl)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5271698 |  |
IC50 | = | 22.0 | nM | 454.55 | CCCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(F)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5276468 |  |
IC50 | = | 22.0 | nM | 466.58 | CCCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5286999 |  |
IC50 | = | 26.0 | nM | 480.61 | CCC[C@@H](C)Oc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |
| CHEMBL5291207 |  |
IC50 | = | 27.0 | nM | 452.56 | CCCOc1ccc(C(C)(C)C)cc1NC(=O)c1nnn(-c2cc(OC)ccc2OC)c1C | Homo sapiens | CHEMBL5239751 | cell-based format |