O75417 | DPOLQ_HUMAN | DNA polymerase theta (POLQ)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00270 | DEAD | 104–272 | |
| PF00271 | Helicase_C | 403–485 | |
| PF00476 | DNA_pol_A | 2098–2584 | |
| PF20470 | HTH_61 | 490–596 | |
| PF21099 | POLQ_helical | 625–785 | |
| PF25453 | DUF7898 | 792–857 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // PRK00254 ]
[ Domain: "SAM-like subdomain in Sec63-like proteins" // KOG0950_2nd ]
[ Domain: "Sec63 N-terminal subdomain-like" // KOG0950_1st ]
[ Domain: "helical bundle in Bacillus stearothermophilus-like DNA polymerase I" // DNA_pol_A_2nd ]
[ Domain: ""fingers" domain in bacteriophage RB69-like DNA polymerase I" // DNA_pol_A_1st ]
[ Domain: "Adenylyl and guanylyl cyclase catalytic domain-like" // DNA_pol_A_3rd ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD_1 ]
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_5 ]
[ Domain: "Ribonuclease H-like" // UNK_F_TYPE ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5204203 |  |
IC50 | = | 0.068 | nM | 524.42 | Cc1nnc(C(=O)NCC#CCN(C(=O)Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c2ccccc2)o1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5175156 |  |
IC50 | = | 0.2 | nM | 519.45 | O=C(NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1)c1cccnc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5206022 |  |
IC50 | = | 0.4 | nM | 519.45 | O=C(NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1)c1ccccn1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5197367 |  |
IC50 | = | 0.51 | nM | 478.39 | O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccc(=O)[nH]1)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5174509 |  |
IC50 | = | 0.72 | nM | 550.48 | O=C(Cc1ncc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ccc(C2CCNC2)cn1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5197173 |  |
IC50 | = | 0.75 | nM | 525.43 | O=C(Cc1ncc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cnn(C2CNC2)c1)c1ccc(F)cc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5170373 |  |
IC50 | = | 0.82 | nM | 456.39 | CC(=O)NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5194637 |  |
IC50 | = | 0.91 | nM | 562.47 | CS(=O)(=O)Cn1cc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5197021 |  |
IC50 | = | 0.99 | nM | 541.43 | CC(C(N)=O)n1cc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5187337 |  |
IC50 | = | 1.2 | nM | 465.4 | Cn1cncc1C#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5188048 |  |
IC50 | = | 1.4 | nM | 463.38 | O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccnn1)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5181369 |  |
IC50 | = | 1.6 | nM | 497.37 | Nc1ncc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5174376 |  |
IC50 | = | 1.7 | nM | 499.39 | Cn1nc(N)cc1C#CCN(C(=O)Cc1ncc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)cc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5429065 |  |
IC50 | = | 2.0 | nM | 433.51 | Cc1ccc(NC(=O)Nc2cncc(-c3ccc(OCC4(C)CCOC4)c(C)c3)n2)cn1 | Homo sapiens | CHEMBL5341415 | assay format |
| CHEMBL5200250 |  |
IC50 | = | 2.1 | nM | 512.38 | COc1ncc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5174283 |  |
IC50 | = | 2.5 | nM | 462.39 | O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccnc1)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5195161 |  |
IC50 | = | 2.9 | nM | 462.39 | O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ccccn1)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5194194 |  |
IC50 | = | 3.9 | nM | 463.38 | O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ncccn1)c1ccccc1 | Homo sapiens | CHEMBL5111529 | cell-based format |
| CHEMBL5208956 |  |
IC50 | = | 4.1 | nM | 429.35 | Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2ccc(F)c(C)c2F)n1 | Homo sapiens | CHEMBL5112234 | single protein format |
| CHEMBL5206029 |  |
IC50 | = | 4.2 | nM | 497.37 | Nc1cnc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 | Homo sapiens | CHEMBL5111529 | cell-based format |