O75385 | ULK1_HUMAN | Serine/threonine-protein kinase ULK1 (ULK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 17~278 | |
| PF12063 | ATG1-like_MIT1 - Atg1-like, MIT domain 1 | 875~960 | |
| PF21127 | ATG1-like_MIT2 - ATG1-like, MIT domain 2 | 972~1044 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // Atg8 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5280560 |  |
IC50 | = | 1.6 | nM | 573.68 | CC(C)[C@H](NC(=O)c1cc(C2C=C3N=C(c4ccc(OCCN5CCCCC5)cc4)C=CN3N2)cs1)C(F)(F)F | Homo sapiens | CHEMBL5250359 | single protein format |
| CHEMBL5266681 |  |
IC50 | = | 2.9 | nM | 450.59 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CC1 | Homo sapiens | CHEMBL5250359 | single protein format |
| CHEMBL4516990 |  |
IC50 | = | 2.9 | nM | 434.59 | CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1 | Homo sapiens | CHEMBL4308982 | single protein format |
| CHEMBL4796600 |  |
IC50 | = | 3.0 | nM | 362.36 | O=C1CCCc2cc(Nc3ncc(C(F)(F)F)c(NC4CC4)n3)ccc21 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4746440 |  |
IC50 | = | 5.0 | nM | 345.33 | FC(F)(F)c1cnc(Nc2ccc3ncccc3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4741912 |  |
IC50 | = | 5.0 | nM | 334.31 | FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL3605055 |  |
IC50 | = | 5.3 | nM | 396.46 | c1ccc2c(Nc3cc(C4CCC4)[nH]n3)nc(Nc3ccc4[nH]cnc4c3)nc2c1 | Homo sapiens | CHEMBL3606871 | cell-based format |
| CHEMBL4782961 |  |
IC50 | = | 6.0 | nM | 335.29 | FC(F)(F)c1cnc(Nc2ccc3nn[nH]c3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4758769 |  |
IC50 | = | 7.0 | nM | 366.34 | FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCCO3)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL5269042 |  |
IC50 | = | 8.3 | nM | 462.47 | O=C(N[C@@H](C1CC1)C(F)(F)F)c1cc(C2C=C3N=C(c4ccc(F)cc4)C=CN3N2)cs1 | Homo sapiens | CHEMBL5250359 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 8.95 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328647 | single protein format |
| CHEMBL4435393 |  |
IC50 | = | 9.0 | nM | 552.61 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380527 | assay format |
| CHEMBL4167070 |  |
IC50 | = | 11.0 | nM | 399.5 | NC1CCCC(C(=O)Nc2ccc3[nH]nc(Nc4cccc5ccccc45)c3c2)C1 | Homo sapiens | CHEMBL4136618 | cell-based format |
| CHEMBL4778997 |  |
IC50 | = | 13.0 | nM | 377.37 | O=C(Nc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1)C1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4779423 |  |
IC50 | = | 13.0 | nM | 354.33 | COc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1OC | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4748400 |  |
IC50 | = | 13.0 | nM | 346.32 | FC(F)(F)c1cnc(Nc2ccc3nccnc3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4794151 |  |
IC50 | = | 14.0 | nM | 334.31 | FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4799009 |  |
IC50 | = | 14.0 | nM | 352.32 | FC(F)(F)c1cnc(Nc2ccc3c(c2)OCCO3)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4795918 |  |
IC50 | = | 14.0 | nM | 325.29 | COc1cncc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)c1 | Homo sapiens | CHEMBL4677633 | cell-based format |
| CHEMBL4792540 |  |
IC50 | = | 16.0 | nM | 345.33 | FC(F)(F)c1cnc(Nc2cnc3ccccc3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677633 | cell-based format |