O75173 | ATS4_HUMAN | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Pfam Domain Table

AccessionDomainRangeColor
PF00090TSP_1 - Thrombospondin type 1 domain524~574
PF01421Reprolysin - Reprolysin (M12B) family zinc metalloprotease218~428
PF05986ADAMTS_spacer1 - ADAM-TS Spacer 1688~803
PF17771ADAMTS_CR_2 - ADAMTS cysteine-rich domain 2439~507
PF19236ADAMTS_CR_3 - ADAMTS cysteine-rich domain580~685

3D structures mapped by conservation among orthologs

[ Domain: "Metalloproteases ("zincins") catalytic domain" // Reprolysin ]

 PyMOL session

[ Domain: "Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins" // KOG3538_1st ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL1683454 IC50 = 0.18 nM 524.63 Cc1cc(F)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683460 IC50 = 0.26 nM 527.69 Cc1nsc(C)c1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683450 IC50 = 0.36 nM 541.09 Cc1cc(Cl)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683458 IC50 = 0.43 nM 521.66 Cc1cc(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c(C)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683449 IC50 = 0.48 nM 595.06 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(C(F)(F)F)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683451 IC50 = 0.48 nM 589.5 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(F)cc2Br)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683457 IC50 = 0.48 nM 520.67 Cc1ccc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683455 IC50 = 0.49 nM 574.64 Cc1cc(C(F)(F)F)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683453 IC50 = 0.52 nM 578.6 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(F)cc2C(F)(F)F)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683461 IC50 = 0.68 nM 521.66 Cc1cc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1615187 IC50 = 0.69 nM 511.62 Cc1noc(C)c1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683444 IC50 = 1.0 nM 549.45 C[C@@H](C[C@@H](CS(=O)(=O)N1CCC(OCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1683447 IC50 = 1.1 nM 561.51 C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL179552 IC50 = 1.1 nM 503.4 CC1(C)C[C@@H](O)CN(S(=O)(=O)c2ccc(OCc3ccc(Cl)cc3Cl)cc2)[C@H]1C(=O)NO Homo sapiens CHEMBL1768099 single protein format
CHEMBL1784371 IC50 = 1.2 nM 573.68 Cc1cc(C(F)(F)F)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 Homo sapiens CHEMBL1787037 single protein format
CHEMBL1784369 IC50 = 1.2 nM 540.13 Cc1cc(Cl)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 Homo sapiens CHEMBL1787037 single protein format
CHEMBL1683443 IC50 = 1.4 nM 469.51 C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)N(O)C=O)c1ncc(F)cn1 Homo sapiens CHEMBL1686369 single protein format
CHEMBL1784359 IC50 = 1.4 nM 528.69 CS(=O)(=O)c1ccc(CCC2CCN(S(=O)(=O)CC3(N(O)C=O)CCOCC3)CC2)c(C2CC2)c1 Homo sapiens CHEMBL1787037 single protein format
CHEMBL1784336 IC50 = 1.9 nM 523.67 Cc1cc(F)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 Homo sapiens CHEMBL1787037 single protein format
CHEMBL1683459 IC50 = 1.9 nM 521.66 Cc1cnc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c1 Homo sapiens CHEMBL1686369 single protein format