O75173 | ATS4_HUMAN | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00090 | TSP_1 - Thrombospondin type 1 domain | 524~574 | |
PF01421 | Reprolysin - Reprolysin (M12B) family zinc metalloprotease | 218~428 | |
PF05986 | ADAMTS_spacer1 - ADAM-TS Spacer 1 | 688~803 | |
PF17771 | ADAMTS_CR_2 - ADAMTS cysteine-rich domain 2 | 439~507 | |
PF19236 | ADAMTS_CR_3 - ADAMTS cysteine-rich domain | 580~685 |
3D structures mapped by conservation among orthologs
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Reprolysin ]
[ Domain: "Disulfide-rich domain in A Disintegrin And Metalloprotease (ADAM) domain-containing proteins" // KOG3538_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL1683454 | IC50 | = | 0.18 | nM | 524.63 | Cc1cc(F)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683460 | IC50 | = | 0.26 | nM | 527.69 | Cc1nsc(C)c1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683450 | IC50 | = | 0.36 | nM | 541.09 | Cc1cc(Cl)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683458 | IC50 | = | 0.43 | nM | 521.66 | Cc1cc(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c(C)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683449 | IC50 | = | 0.48 | nM | 595.06 | C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(C(F)(F)F)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683451 | IC50 | = | 0.48 | nM | 589.5 | C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(F)cc2Br)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683457 | IC50 | = | 0.48 | nM | 520.67 | Cc1ccc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683455 | IC50 | = | 0.49 | nM | 574.64 | Cc1cc(C(F)(F)F)ccc1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683453 | IC50 | = | 0.52 | nM | 578.6 | C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(F)cc2C(F)(F)F)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683461 | IC50 | = | 0.68 | nM | 521.66 | Cc1cc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1615187 | IC50 | = | 0.69 | nM | 511.62 | Cc1noc(C)c1CCC1CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c2ncc(F)cn2)N(O)C=O)CC1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683444 | IC50 | = | 1.0 | nM | 549.45 | C[C@@H](C[C@@H](CS(=O)(=O)N1CCC(OCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1683447 | IC50 | = | 1.1 | nM | 561.51 | C[C@@H](C[C@@](C)(CS(=O)(=O)N1CCC(CCc2ccc(Cl)cc2Cl)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL179552 | IC50 | = | 1.1 | nM | 503.4 | CC1(C)C[C@@H](O)CN(S(=O)(=O)c2ccc(OCc3ccc(Cl)cc3Cl)cc2)[C@H]1C(=O)NO | Homo sapiens | CHEMBL1768099 | single protein format | |
CHEMBL1784371 | IC50 | = | 1.2 | nM | 573.68 | Cc1cc(C(F)(F)F)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 | Homo sapiens | CHEMBL1787037 | single protein format | |
CHEMBL1784369 | IC50 | = | 1.2 | nM | 540.13 | Cc1cc(Cl)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 | Homo sapiens | CHEMBL1787037 | single protein format | |
CHEMBL1683443 | IC50 | = | 1.4 | nM | 469.51 | C[C@@H](C[C@@H](CS(=O)(=O)N1CCN(c2ccc(F)cc2)CC1)N(O)C=O)c1ncc(F)cn1 | Homo sapiens | CHEMBL1686369 | single protein format | |
CHEMBL1784359 | IC50 | = | 1.4 | nM | 528.69 | CS(=O)(=O)c1ccc(CCC2CCN(S(=O)(=O)CC3(N(O)C=O)CCOCC3)CC2)c(C2CC2)c1 | Homo sapiens | CHEMBL1787037 | single protein format | |
CHEMBL1784336 | IC50 | = | 1.9 | nM | 523.67 | Cc1cc(F)ccc1CCC1CCN(S(=O)(=O)CC2(N(O)C=O)CCN(C(=O)C3CCC3)CC2)CC1 | Homo sapiens | CHEMBL1787037 | single protein format | |
CHEMBL1683459 | IC50 | = | 1.9 | nM | 521.66 | Cc1cnc(C)c(CCC2CCN(S(=O)(=O)C[C@](C)(C[C@H](C)c3ncc(F)cn3)N(O)C=O)CC2)c1 | Homo sapiens | CHEMBL1686369 | single protein format |