O75164 | KDM4A_HUMAN | Lysine-specific demethylase 4A (KDM4A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02373 | JmjC - JmjC domain, hydroxylase | 175~291 | |
| PF02375 | JmjN - jmjN domain | 15~49 | |
| PF13831 | PHD_2 - PHD-finger | 732~766 | |
| PF13832 | zf-HC5HC2H_2 - PHD-zinc-finger like domain | 774~884 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 902~936 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 960~994 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // LBR_tudor_1 ]
[ Domain: "Double-stranded beta-helix" // JmjC ]
- 2GP3
- 2GP5
- 2OQ6
- 2OQ7
- 2OS2
- 2OT7
- 2OX0
- 2P5B
- 2PXJ
- 2Q8C
- 2Q8D
- 2Q8E
- 2VD7
- 2WWJ
- 2YBK
- 2YBP
- 2YBS
- 3NJY
- 3PDQ
- 3RVH
- 3U4S
- 4AI9
- 4BIS
- 4GD4
- 4URA
- 4V2V
- 4V2W
- 5A7N
- 5A7O
- 5A7P
- 5A7Q
- 5A7S
- 5A7W
- 5A80
- 5ANQ
- 5F2S
- 5F2W
- 5F32
- 5F37
- 5F39
- 5F3C
- 5F3E
- 5F3G
- 5F3I
- 5F5I
- 5FPV
- 5FWE
- 5FY8
- 5FYC
- 5FYH
- 5FYI
- 5LY1
- 5LY2
- 5TVR
- 5TVS
- 5VGI
- 5VMP
- 6CG1
- 6CG2
- 6G5W
- 6G5X
- 6H4O
- 6H4P
- 6H4Q
- 6H4R
- 6H4S
- 6H4T
- 6H4U
- 6H4V
- 6H4W
- 6H4X
- 6H4Y
- 6H8P
- 6HGT
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4567766 |  |
IC50 | = | 56.0 | nM | 477.57 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6cccnc6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4440395 |  |
IC50 | = | 59.0 | nM | 513.65 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CCN6CCOCC6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4438034 |  |
IC50 | = | 68.0 | nM | 478.56 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(-c6cncnc6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4516101 |  |
IC50 | = | 71.0 | nM | 551.62 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(CN6CCCC6)cc(C(F)(F)F)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4466130 |  |
IC50 | = | 77.0 | nM | 513.65 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5ccc(CCN6CCOCC6)cc5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL3775894 |  |
IC50 | = | 80.0 | nM | 469.38 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cc(Cl)cc(Cl)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL3778805 | assay format |
| CHEMBL4592908 |  |
IC50 | = | 83.0 | nM | 483.62 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(CN6CCCC6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4447515 |  |
IC50 | = | 84.0 | nM | 418.48 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(F)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4558689 |  |
IC50 | = | 88.0 | nM | 478.56 | O=c1[nH]cnc2c(-n3cc(CCN4CCC(c5cccc(-c6cncnc6)c5)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4585876 |  |
IC50 | = | 93.0 | nM | 471.61 | CN(C)CCc1ccc(C2CCN(CCc3cnn(-c4nccc5c(=O)[nH]cnc45)c3)CC2)cc1 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL3786952 |  |
IC50 | = | 99.0 | nM | 343.77 | Cc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 | Homo sapiens | CHEMBL4223299 | single protein format |
| CHEMBL4283431 |  |
IC50 | = | 100.0 | nM | 307.35 | Cc1ccccc1CCn1cnc(-c2cc(C(=O)O)ccn2)c1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4284008 |  |
IC50 | = | 100.0 | nM | 297.29 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4286972 |  |
IC50 | = | 100.0 | nM | 322.37 | CN(CCn1cnc(-c2cc(C(=O)O)ccn2)c1)c1ccccc1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4286102 |  |
IC50 | = | 100.0 | nM | 356.81 | CN(CCn1cnc(-c2cc(C(=O)O)ccn2)c1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4290188 |  |
IC50 | = | 100.0 | nM | 382.85 | O=C(O)c1ccnc(-c2cn(CCN3CCCc4cc(Cl)ccc43)cn2)c1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4449500 |  |
IC50 | = | 100.0 | nM | 426.52 | O=c1[nH]cnc2c(-n3cc(CCN4CCC5(CCc6ccccc65)CC4)cn3)nccc12 | Homo sapiens | CHEMBL4353688 | assay format |
| CHEMBL4293159 |  |
IC50 | = | 100.0 | nM | 343.39 | O=C(O)c1ccnc(-c2cn(CCc3cccc4ccccc34)cn2)c1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4295253 |  |
IC50 | = | 100.0 | nM | 323.33 | O=C(O)c1ccnc(-c2cn(C3CCc4c(F)cccc43)cn2)c1 | Homo sapiens | CHEMBL4257284 | assay format |
| CHEMBL4286665 |  |
IC50 | = | 100.0 | nM | 323.33 | O=C(O)c1ccnc(-c2cn(C3CCc4ccc(F)cc43)cn2)c1 | Homo sapiens | CHEMBL4257284 | assay format |