O60825 | F262_HUMAN | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00300 | His_Phos_1 - Histidine phosphatase superfamily (branch 1) | 252~435 | |
| PF01591 | 6PF2K - 6-phosphofructo-2-kinase | 27~249 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // 6PF2K ]
[ Domain: "Phosphoglycerate mutase-like" // His_Phos_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3422677 |  |
IC50 | = | 15.0 | nM | 403.49 | CC(C)Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422678 |  |
IC50 | = | 25.0 | nM | 456.51 | Cc1noc(C)c1Cn1nc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422674 |  |
IC50 | = | 108.0 | nM | 491.55 | CN1Cc2cc(-n3cc(C#N)c4cc(Oc5ccc(NC(=O)[C@@H]6CCCN6)cc5)ccc43)ccc2C1=O | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3421733 |  |
IC50 | = | 141.0 | nM | 415.54 | CC(C)Cn1cc(C#N)c2cc(N(C)c3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422676 |  |
IC50 | = | 159.0 | nM | 455.52 | Cc1noc(C)c1Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422675 |  |
IC50 | = | 188.0 | nM | 436.52 | N#Cc1cn(Cc2ccccc2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3421734 |  |
IC50 | = | 190.0 | nM | 418.57 | CC(C)Cn1cc(C#N)c2cc(Sc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422673 |  |
IC50 | = | 374.0 | nM | 422.49 | N#Cc1cn(-c2ccccc2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422651 |  |
IC50 | = | 384.0 | nM | 402.5 | CC(C)Cn1cc(C#N)c2cc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)ccc21 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3422672 |  |
IC50 | = | 429.0 | nM | 444.54 | N#Cc1cn(CC2CCOCC2)c2ccc(Oc3ccc(NC(=O)[C@@H]4CCCN4)cc3)cc12 | Homo sapiens | CHEMBL3425139 | single protein format |
| CHEMBL3421731 |  |
IC50 | = | 818.0 | nM | 415.5 | Cn1cc(-c2cn(C)c3ccc(Oc4ccc(NC(=O)[C@@H]5CCCN5)cc4)cc23)cn1 | Homo sapiens | CHEMBL3425139 | single protein format |