O60725 | ICMT_HUMAN | Protein-S-isoprenylcysteine O-methyltransferase (ICMT)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04140 | ICMT - Isoprenylcysteine carboxyl methyltransferase (ICMT) family | 164~257 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4443354 |  |
IC50 | = | 0.002 | nM | 377.42 | C[C@H](COc1cccc(-n2ccnc2C2CC2)c1)Oc1ccc(C#N)cc1F | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4558383 |  |
IC50 | = | 0.003 | nM | 389.46 | COc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-n2ccnc2C2CC2)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4583704 |  |
IC50 | = | 0.08 | nM | 363.42 | COc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-n2ccnc2C)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4446351 |  |
IC50 | = | 0.1 | nM | 379.85 | N#Cc1ccc(OCCOc2cccc(-n3ccnc3C3CC3)c2)c(Cl)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4449942 |  |
IC50 | = | 0.16 | nM | 345.4 | N#Cc1ccc(OCCOc2cccc(-n3ccnc3C3CC3)c2)cc1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4446048 |  |
IC50 | = | 0.2 | nM | 349.39 | COc1cc(C#N)ccc1OCCOc1cccc(-n2ccnc2C)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4468997 |  |
IC50 | = | 0.2 | nM | 353.81 | Cc1nccn1-c1cccc(OCCOc2ccc(C#N)cc2Cl)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4464629 |  |
IC50 | = | 0.7 | nM | 351.38 | C[C@@H](COc1cccc(-c2ccnn2C)c1)Oc1ccc(C#N)cc1F | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL4473893 |  |
IC50 | = | 0.9 | nM | 349.39 | COc1cc(C#N)ccc1OCCOc1cccc(-c2ccnn2C)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL1800705 |  |
IC50 | = | 1.0 | nM | 367.53 | COc1cccc(NCCC2(c3ccccc3)CC(C)(C)OC(C)(C)C2)c1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL4445788 |  |
IC50 | = | 1.6 | nM | 347.42 | Cc1cc(C#N)ccc1O[C@@H](C)COc1cccc(-c2ccnn2C)c1 | Homo sapiens | CHEMBL4307065 | cell-based format |
| CHEMBL1800516 |  |
IC50 | = | 3.8 | nM | 349.93 | CC1(C)CC(CCNc2cccc(Cl)c2)(c2cccs2)CCO1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800513 |  |
IC50 | = | 8.0 | nM | 357.47 | COc1cccc(NCCC2(c3cccc(F)c3)CCOC(C)(C)C2)c1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800715 |  |
IC50 | = | 10.0 | nM | 339.48 | COc1cccc(NCC[C@@]2(c3ccccc3)CCOC(C)(C)C2)c1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800522 |  |
IC50 | = | 15.0 | nM | 337.51 | CC1(C)CC(CCNc2ccccc2)(c2ccccc2)CC(C)(C)O1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800426 |  |
IC50 | = | 15.0 | nM | 339.48 | COc1cccc(NCCC2(c3ccccc3)CCOC(C)(C)C2)c1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800514 |  |
IC50 | = | 19.0 | nM | 345.51 | COc1cccc(NCCC2(c3cccs3)CCOC(C)(C)C2)c1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800485 |  |
IC50 | = | 25.0 | nM | 343.9 | CC1(C)CC(CCNc2cccc(Cl)c2)(c2ccccc2)CCO1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800498 |  |
IC50 | = | 25.0 | nM | 361.89 | CC1(C)CC(CCNc2ccc(F)c(Cl)c2)(c2ccccc2)CCO1 | Homo sapiens | CHEMBL1803626 | single protein format |
| CHEMBL1800501 |  |
IC50 | = | 26.0 | nM | 354.45 | CC1(C)CC(CCNc2cccc([N+](=O)[O-])c2)(c2ccccc2)CCO1 | Homo sapiens | CHEMBL1803626 | single protein format |