O60678 | ANM3_HUMAN | Protein arginine N-methyltransferase 3 (PRMT3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06325 | PrmA - Ribosomal protein L11 methyltransferase (PrmA) | 255~328 | |
| PF21137 | ANM3_C2H2_Zf - Protein arginine N-methyltransferase 3, C2H2 zinc finger domain | 78~123 | |
| PF21336 | ANM3_zf-C2H2 - Protein arginine N-methyltransferase 3, C2H2 zinc finger | 49~66 | |
| PF22528 | PRMT_C - Arginine methyltransferase oligomerization subdomain | 364~522 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3901808 |  |
IC50 | = | 4.0 | nM | 287.41 | CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3859038 | single protein format |
| CHEMBL4079503 |  |
IC50 | = | 10.0 | nM | 316.34 | O=C(NCC(=O)N1CCCC1)Nc1ccc2cnc(F)cc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4076640 |  |
IC50 | = | 17.0 | nM | 326.4 | O=C(NCC(=O)N1CCCCCC1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4061429 |  |
IC50 | = | 19.0 | nM | 332.79 | O=C(NCC(=O)N1CCCC1)Nc1cc(Cl)c2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4094513 |  |
IC50 | = | 22.0 | nM | 306.86 | CN(CCN)Cc1ccccc1Sc1ccccc1Cl | Homo sapiens | CHEMBL4026501 | single protein format |
| CHEMBL4061085 |  |
IC50 | = | 22.0 | nM | 338.41 | O=C(NCC(=O)N1C2CCCC1CC2)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4086964 |  |
IC50 | = | 35.0 | nM | 348.35 | O=C(NCC(=O)N1CCC(F)(F)CC1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4095787 |  |
IC50 | = | 36.0 | nM | 312.37 | Cc1cc2cnccc2cc1NC(=O)NCC(=O)N1CCCC1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4082966 |  |
IC50 | = | 46.0 | nM | 324.38 | O=C(NCC(=O)N1C2CCC1CC2)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4105488 |  |
IC50 | = | 55.0 | nM | 338.41 | O=C(NCC(=O)N1CC2CCCC2C1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4097428 |  |
IC50 | = | 61.0 | nM | 284.32 | O=C(NCC(=O)N1CCC1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4087094 |  |
IC50 | = | 84.0 | nM | 312.37 | O=C(NCC(=O)N1CCCCC1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4082359 |  |
IC50 | = | 87.0 | nM | 326.4 | CN(C(=O)CNC(=O)Nc1ccc2cnccc2c1)C1CCCC1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4072005 |  |
IC50 | = | 91.0 | nM | 298.35 | O=C(NCC(=O)N1CCCC1)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027816 | cell-based format |
| CHEMBL4065941 |  |
IC50 | = | 114.0 | nM | 300.36 | CCN(CC)C(=O)CNC(=O)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4077534 |  |
IC50 | = | 134.0 | nM | 316.34 | O=C(NCC(=O)N1CCCC1)Nc1cc2ccncc2cc1F | Homo sapiens | CHEMBL4027816 | cell-based format |
| CHEMBL4071410 |  |
IC50 | = | 134.0 | nM | 326.4 | CC1CCC(C)N1C(=O)CNC(=O)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027816 | cell-based format |
| CHEMBL4090733 |  |
IC50 | = | 150.0 | nM | 272.31 | CN(C)C(=O)CNC(=O)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4074611 |  |
IC50 | = | 158.0 | nM | 284.32 | O=C(CNC(=O)Nc1ccc2cnccc2c1)NC1CC1 | Homo sapiens | CHEMBL4027812 | single protein format |
| CHEMBL4097411 |  |
IC50 | = | 166.0 | nM | 356.38 | COC(=O)[C@@H]1CCCN1C(=O)CNC(=O)Nc1ccc2cnccc2c1 | Homo sapiens | CHEMBL4027812 | single protein format |