ProtHub

O60674 | JAK2_HUMAN | Tyrosine-protein kinase JAK2 (JAK2)

Pfam Domain Table

Accession	Domain	Range
PF07714	PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase	546~805
PF07714	PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase	849~1120
PF17887	Jak1_Phl - Jak1 pleckstrin homology-like domain	302~381
PF18377	FERM_F2 - FERM F2 acyl-CoA binding protein-like domain	143~261
PF18379	FERM_F1 - FERM F1 ubiquitin-like domain	39~134
PF21990	SH2_1 - SH2 domain	399~501

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL3652408	IC50	=	0.00405	nM	465.62	COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1	Homo sapiens	CHEMBL3707948	single protein format
CHEMBL3652407	IC50	=	0.00767	nM	463.65	CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1	Homo sapiens	CHEMBL3707948	single protein format
CHEMBL3665151	IC50	=	0.0089	nM	386.48	CS(=O)(=O)N1CCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)CC1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665130	IC50	=	0.0106	nM	366.43	COC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665128	IC50	=	0.0108	nM	358.43	CS(=O)(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3652404	IC50	=	0.0165	nM	421.57	C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO	Homo sapiens	CHEMBL3707948	single protein format
CHEMBL3665202	IC50	=	0.0172	nM	541.73	CN1CCN(c2ncc(-c3cnc4[nH]ccc4n3)c(N[C@H]3CCCN(S(=O)(=O)CCC(C)(C)C)C3)n2)CC1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665129	IC50	=	0.0191	nM	350.43	CC(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665180	IC50	=	0.0196	nM	430.54	CC(C)CS(=O)(=O)N1CCC[C@H](Nc2nc(N)ncc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3652402	IC50	=	0.0199	nM	421.57	C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12	Homo sapiens	CHEMBL3707948	single protein format
CHEMBL3665176	IC50	=	0.0201	nM	388.45	CS(=O)(=O)N1CC[C@@H](O)[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665131	IC50	=	0.0209	nM	386.48	CS(=O)(=O)N1CCCCC(Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665199	IC50	=	0.0221	nM	513.63	CS(=O)(=O)N1CCC[C@H](Nc2nc(N3CCC(CC(N)=O)CC3)ncc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665123	IC50	=	0.0228	nM	336.4	CC(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665127	IC50	=	0.0276	nM	338.37	COC(=O)N1CC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665119	IC50	=	0.0292	nM	372.45	CS(=O)(=O)N1CCC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665188	IC50	=	0.0293	nM	489.67	CSc1ncc(-c2cnc3[nH]ccc3n2)c(N[C@H]2CCCN(S(=O)(=O)CCC(C)(C)C)C2)n1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665122	IC50	=	0.0296	nM	358.43	CS(=O)(=O)N1CC[C@@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665222	IC50	=	0.0332	nM	411.49	C[C@H]1C[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)CN(S(=O)(=O)CC#N)C1	Homo sapiens	CHEMBL3707646	single protein format
CHEMBL3665147	IC50	=	0.035	nM	376.39	FC(F)(F)CN1CCC[C@H](Nc2ncccc2-c2cnc3[nH]ccc3n2)C1	Homo sapiens	CHEMBL3707646	single protein format

Pfam Domain Table

[ Domain: "PH domain-like" // FERM_C_TYK2 ]

[ Domain: "Acyl-CoA binding protein-like" // B41_C ]

[ Domain: "SH2" // SH2_1 ]

[ Domain: "Ubiquitin-like" // B41_N ]

[ Domain: "Protein kinase" // Pkinase_Tyr ]