O60658 | PDE8A_HUMAN | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 555~807 | |
| PF00989 | PAS - PAS fold | 219~324 | |
| PF23198 | PDE8A_N - PDE8A-like, N-terminal domain | 75~216 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5169811 |  |
IC50 | = | 0.7 | nM | 400.39 | Nc1nc(C(F)(F)F)nc2c1nnn2C[C@H]1CN(Cc2nccs2)CCO1 | Homo sapiens | CHEMBL5128078 | single protein format |
| CHEMBL1779976 |  |
IC50 | = | 1.8 | nM | 452.56 | Cc1cccc(CNC(=O)C2CN(Cc3nc(-c4ccccc4)oc3C)Cc3ccccc32)n1 | Homo sapiens | CHEMBL1780333 | single protein format |
| CHEMBL1779978 |  |
IC50 | = | 1.8 | nM | 404.51 | Cc1cccc(CNC(=O)C2CCCN(Cc3nc(-c4ccccc4)oc3C)C2)n1 | Homo sapiens | CHEMBL1780333 | single protein format |
| CHEMBL1779984 |  |
IC50 | = | 1.8 | nM | 432.57 | CC[C@@H]1C[C@@H](C(=O)NCc2cccc(C)n2)CN(Cc2nc(-c3ccccc3)oc2C)C1 | Homo sapiens | CHEMBL1780333 | single protein format |
| CHEMBL2070735 |  |
IC50 | = | 1.9 | nM | 346.42 | Cc1nc(N)c2nnn(C[C@H]3CN(Cc4nccs4)CCO3)c2n1 | Homo sapiens | CHEMBL2073624 | single protein format |
| CHEMBL4762103 |  |
IC50 | = | 10.0 | nM | 354.75 | C[C@@H](c1cc(OCC(F)F)ccn1)n1cnc2c(N)nc(Cl)nc21 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL3646900 |  |
IC50 | = | 15.0 | nM | 558.59 | N#Cc1cc(Cn2c(=O)c3cc(OC(CF)CF)ccc3n(C3CCN(C=O)CC3)c2=O)ccc1-c1ccccc1 | Homo sapiens | CHEMBL3706022 | single protein format |
| CHEMBL4753446 |  |
IC50 | = | 26.0 | nM | 354.75 | CC(c1cc(OCC(F)F)ccn1)n1cnc2c(N)nc(Cl)nc21 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4790482 |  |
IC50 | = | 46.0 | nM | 328.81 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2CCCC2)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4800434 |  |
IC50 | = | 130.0 | nM | 354.78 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(-c2ccccc2F)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL3646893 |  |
IC50 | = | 140.0 | nM | 517.53 | COc1ccc(Cn2c(=O)c3cc(OC(CF)CF)ccc3n(C3CCN(C=O)CC3)c2=O)cc1OC | Homo sapiens | CHEMBL3706022 | single protein format |
| CHEMBL5407967 |  |
IC50 | = | 194.0 | nM | 553.66 | COc1c(OCC2CC2)cc2oc3cc4c(c(OCc5ccncc5)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 | Homo sapiens | CHEMBL5339436 | assay format |
| CHEMBL4789101 |  |
IC50 | = | 220.0 | nM | 344.81 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2CCOCC2)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4778928 |  |
IC50 | = | 240.0 | nM | 326.75 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(-c2ccco2)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4745958 |  |
IC50 | = | 250.0 | nM | 342.79 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2=CCOCC2)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4798107 |  |
IC50 | = | 250.0 | nM | 326.79 | Nc1nc(Cl)nc2c1ncn2Cc1cccc(C2=CCCC2)n1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL5288859 |  |
IC50 | = | 280.0 | nM | 333.35 | CCc1nnc2c3ccccc3nc(Nc3cccc(C(=O)O)c3)n12 | Homo sapiens | CHEMBL5226660 | single protein format |
| CHEMBL4757863 |  |
IC50 | = | 360.0 | nM | 340.72 | Nc1nc(Cl)nc2c1ncn2Cc1cc(OCC(F)F)ccn1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4747327 |  |
IC50 | = | 410.0 | nM | 295.13 | Nc1nc(Cl)nc2c1ncn2Cc1cc(Cl)ccn1 | Homo sapiens | CHEMBL4706222 | assay format |
| CHEMBL4750412 |  |
IC50 | = | 660.0 | nM | 290.71 | COc1ccnc(Cn2cnc3c(N)nc(Cl)nc32)c1 | Homo sapiens | CHEMBL4706222 | assay format |