O60427 | FADS1_HUMAN | Acyl-CoA (8-3)-desaturase (FADS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00173 | Cyt-b5 - Cytochrome b5-like Heme/Steroid binding domain | 21~93 | |
| PF00487 | FA_desaturase - Fatty acid desaturase | 156~416 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4084502 |  |
IC50 | = | 0.52 | nM | 330.75 | C[C@H]1[C@H](c2ccc(F)cc2)OC(=O)N1c1cc(Cl)cc(C#N)c1 | Homo sapiens | CHEMBL4026560 | cell-based format |
| CHEMBL4856454 |  |
IC50 | = | 1.1 | nM | 394.25 | O=c1c(-c2cnn(CCC(F)(F)F)c2)c(C(F)(F)F)nc2ccc(F)cn12 | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL4879015 |  |
IC50 | = | 1.2 | nM | 460.71 | Cc1cc2nc(C(F)(F)F)c(-c3cnn(CC(F)(F)C(F)(F)F)c3)c(=O)n2cc1Cl | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL5278664 |  |
IC50 | = | 1.5 | nM | 321.31 | C[C@@H]1[C@@H](c2ccc(F)cc2)OC(=O)N1c1cc(C#N)cc(C#N)c1 | Homo sapiens | CHEMBL5260606 | cell-based format |
| CHEMBL4064555 |  |
IC50 | = | 1.5 | nM | 321.31 | C[C@H]1[C@H](c2ccc(F)cc2)OC(=O)N1c1cc(C#N)cc(C#N)c1 | Homo sapiens | CHEMBL4026560 | cell-based format |
| CHEMBL4874614 |  |
IC50 | = | 1.6 | nM | 487.28 | CN(C(=O)F)c1ccn2c(=O)c(-c3cnn(CC(F)(F)C(F)(F)F)c3)c(C(F)(F)F)nc2c1 | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL4872983 |  |
IC50 | = | 1.7 | nM | 426.27 | Cc1ccc2nc(C(F)(F)F)c(-c3cnn(CC(F)(F)C(F)(F)F)c3)c(=O)n2c1 | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL4439992 |  |
IC50 | = | 1.9 | nM | 443.47 | CC(=O)NCCSc1nc2cscc2c(=O)n1-c1ccc(OCC(F)(F)F)cc1 | Homo sapiens | CHEMBL4433174 | cell-based format |
| CHEMBL4855704 |  |
IC50 | = | 2.1 | nM | 430.23 | O=c1c(-c2cnn(CC(F)(F)C(F)(F)F)c2)c(C(F)(F)F)nc2ccc(F)cn12 | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL4868627 |  |
IC50 | = | 2.4 | nM | 410.7 | O=c1c(-c2cnn(CCC(F)(F)F)c2)c(C(F)(F)F)nc2ccc(Cl)cn12 | Homo sapiens | CHEMBL4837102 | cell membrane format |
| CHEMBL4102458 |  |
IC50 | = | 3.7 | nM | 314.29 | C[C@H]1[C@H](c2ccc(F)cc2)OC(=O)N1c1cc(F)cc(C#N)c1 | Homo sapiens | CHEMBL4026560 | cell-based format |
| CHEMBL4060775 |  |
IC50 | = | 4.1 | nM | 287.29 | COc1cccc(N2CC(c3ccc(F)cc3)OC2=O)c1 | Homo sapiens | CHEMBL4026560 | cell-based format |
| CHEMBL3608796 |  |
IC50 | = | 5.0 | nM | 278.14 | Clc1cccc(Nc2n[nH]c3ccc(Cl)cc23)c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL3608798 |  |
IC50 | = | 6.0 | nM | 257.72 | Cc1ccc2[nH]nc(Nc3cccc(Cl)c3)c2c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL3608800 |  |
IC50 | = | 8.0 | nM | 273.72 | COc1ccc2[nH]nc(Nc3cccc(Cl)c3)c2c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL4070383 |  |
IC50 | = | 8.7 | nM | 296.3 | C[C@H]1[C@H](c2ccc(F)cc2)OC(=O)N1c1cccc(C#N)c1 | Homo sapiens | CHEMBL4026560 | cell-based format |
| CHEMBL329672 |  |
IC50 | = | 11.0 | nM | 255.71 | Clc1cccc(Nc2ncnc3ccccc23)c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL3608697 |  |
IC50 | = | 15.0 | nM | 277.71 | COc1ccc(O)c(C(=O)Nc2cccc(Cl)c2)c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL3608700 |  |
IC50 | = | 17.0 | nM | 253.73 | Clc1cccc(Nc2cccc3ccccc23)c1 | Homo sapiens | CHEMBL3611102 | assay format |
| CHEMBL3608699 |  |
IC50 | = | 18.0 | nM | 254.72 | Clc1cccc(Nc2ccnc3ccccc23)c1 | Homo sapiens | CHEMBL3611102 | assay format |