O60341 | KDM1A_HUMAN | Lysine-specific histone demethylase 1A (KDM1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01593 | Amino_oxidase - Flavin containing amine oxidoreductase | 288~825 | |
| PF04433 | SWIRM - SWIRM domain | 184~264 |
3D structures mapped by conservation among orthologs
[ Domain: "tri-helical" // SWIRM ]
- 2COM
- 2DW4
- 2EJR
- 2H94
- 2HKO
- 2IW5
- 2L3D
- 2UXN
- 2UXX
- 2V1D
- 2X0L
- 2XAF
- 2XAG
- 2XAH
- 2XAJ
- 2XAQ
- 2XAS
- 2Y48
- 2Z3Y
- 2Z5U
- 3ABT
- 3ABU
- 3ZMS
- 3ZMT
- 3ZMU
- 3ZMV
- 3ZMZ
- 3ZN0
- 3ZN1
- 4BAY
- 4CZZ
- 4KUM
- 4UV8
- 4UV9
- 4UVA
- 4UVB
- 4UVC
- 4UXN
- 4XBF
- 5H6Q
- 5H6R
- 5IT3
- 5L3B
- 5L3C
- 5L3D
- 5L3E
- 5L3F
- 5L3G
- 5LBQ
- 5LGN
- 5LGT
- 5LGU
- 5LHG
- 5LHH
- 5LHI
- 5X60
- 5YJB
- 6E1F
- 6NQM
- 6NQU
- 6NR5
[ Domain: "FAD-linked reductases-C" // Amino_oxidase_2nd ]
[ Domain: "FAD/NAD(P)-binding domain" // Amino_oxidase_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4798849 |  |
IC50 | = | 0.05 | nM | 494.64 | Cn1c(C(=O)Nc2cccc3c2N(Cc2ccc(OC4CCNCC4)cc2)CCC3)cc2ccccc21 | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4762799 |  |
IC50 | = | 0.06 | nM | 526.66 | O=C(Nc1cccc2c1N(Cc1ccc(OC3CCNCC3)cc1)CCC2)c1cc2ccccc2n1CCF | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4639944 |  |
IC50 | = | 0.1 | nM | 474.67 | Cn1c(-c2nc(C3CCC3)cn2CCCc2ccc(OC3CCNCC3)cc2)cc2sccc21 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4785635 |  |
IC50 | = | 0.1 | nM | 519.67 | CCOCc1cccc(NC(=O)c2cc3sccc3n2C)c1COc1ccc(OC[C@H]2CCNC2)cc1 | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4632810 |  |
IC50 | = | 0.13 | nM | 478.66 | CCCc1cn(CCOc2ccc(OC3CCCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4639941 |  |
IC50 | = | 0.13 | nM | 476.69 | CCCc1cn(CCCc2ccc(OC3CCCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4802155 |  |
IC50 | = | 0.14 | nM | 336.4 | Nc1nnc(CN[C@@H]2C[C@H]2c2ccc(OCc3ccccc3)cc2)o1 | Homo sapiens | CHEMBL5127903 | single protein format |
| CHEMBL4641768 |  |
IC50 | = | 0.14 | nM | 476.69 | CCCc1cn(CCCc2ccc(OCC3CCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4776575 |  |
IC50 | = | 0.15 | nM | 508.67 | CCn1c(C(=O)Nc2cccc3c2N(Cc2ccc(OC4CCNCC4)cc2)CCC3)cc2ccccc21 | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4776338 |  |
IC50 | = | 0.15 | nM | 543.11 | O=C(Nc1cccc2c1N(Cc1ccc(OC3CCNCC3)cc1)CCC2)c1cc2ccccc2n1CCCl | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4642214 |  |
IC50 | = | 0.16 | nM | 488.7 | Cn1c(-c2nc(C3CCC3)cn2CCCc2ccc(OC3CCCNCC3)cc2)cc2sccc21 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4635889 |  |
IC50 | = | 0.17 | nM | 462.66 | CCc1cn(CCCc2ccc(OC3CCCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4649085 |  |
IC50 | = | 0.18 | nM | 462.66 | CCCc1cn(CCCc2ccc(OC3CCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4759347 |  |
IC50 | = | 0.18 | nM | 522.69 | CC(C)n1c(C(=O)Nc2cccc3c2N(Cc2ccc(OC4CCNCC4)cc2)CCC3)cc2ccccc21 | Homo sapiens | CHEMBL4686623 | single protein format |
| CHEMBL4639413 |  |
IC50 | = | 0.19 | nM | 476.65 | Cn1c(-c2nc(C3CCC3)cn2CCOc2ccc(OC3CCNCC3)cc2)cc2sccc21 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4649563 |  |
IC50 | = | 0.2 | nM | 464.64 | CCCc1cn(CCOc2ccc(OC3CCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4645937 |  |
IC50 | = | 0.21 | nM | 490.67 | Cn1c(-c2nc(C3CCC3)cn2CCOc2ccc(OC3CCCNCC3)cc2)cc2sccc21 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4634153 |  |
IC50 | = | 0.25 | nM | 488.7 | Cn1c(-c2nc(C3CCC3)cn2CCCc2ccc(OCC3CCNCC3)cc2)cc2sccc21 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4642738 |  |
IC50 | = | 0.27 | nM | 448.64 | CCc1cn(CCCc2ccc(OC3CCNCC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |
| CHEMBL4637660 |  |
IC50 | = | 0.28 | nM | 448.64 | CCc1cn(CCCc2ccc(OCC3CCNC3)cc2)c(-c2cc3sccc3n2C)n1 | Homo sapiens | CHEMBL4615777 | assay format |