O60285 | NUAK1_HUMAN | NUAK family SNF1-like kinase 1 (NUAK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 55~306 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5176650 |  |
IC50 | = | 1.4 | nM | 335.41 | Cc1c[nH]c(=O)c2c1[nH]c1ccc3cc(OCCN(C)C)ccc3c12 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL4303523 |  |
IC50 | = | 1.5 | nM | 497.0 | CCC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1 | Homo sapiens | CHEMBL5096564 | assay format |
| CHEMBL3780091 |  |
IC50 | = | 2.0 | nM | 323.4 | N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 | Homo sapiens | CHEMBL3784252 | single protein format |
| CHEMBL5305160 |  |
IC50 | = | 3.0 | nM | 469.59 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 | Homo sapiens | CHEMBL5345923 | single protein format |
| CHEMBL5199998 |  |
IC50 | = | 3.0 | nM | 373.43 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(S(C)(=O)=O)ncc21 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL5173501 |  |
IC50 | = | 3.7 | nM | 355.37 | C[C@H]1CNC(=O)c2cnn3cc(cnc23)N[C@H](C)c2cc(F)cc(c2)O1 | Homo sapiens | CHEMBL5096564 | assay format |
| CHEMBL4116008 |  |
IC50 | = | 4.0 | nM | 445.55 | CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 4.2 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479759 | assay format |
| CHEMBL5196626 |  |
IC50 | = | 4.8 | nM | 375.47 | Cc1c[nH]c(=O)c2c1[nH]c1ccc3cc(OCCN4CCCCC4)ccc3c12 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL3115681 |  |
IC50 | = | 4.95 | nM | 429.53 | CN1CCN(c2ccc(Nc3ncc4cc(C#N)c(=O)n(C5CCCC5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL3117359 | single protein format |
| CHEMBL3884319 |  |
IC50 | = | 5.0 | nM | 386.45 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876037 | assay format |
| CHEMBL577784 |  |
IC50 | = | 5.0 | nM | 591.48 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL5185351 |  |
IC50 | = | 6.0 | nM | 471.57 | Cc1cc(Nc2ncc3c(n2)N(C)c2ccccc2C(=O)N3C)ccc1C(=O)N1CCN(C)CC1 | Homo sapiens | CHEMBL5096564 | assay format |
| CHEMBL5192992 |  |
IC50 | = | 7.0 | nM | 418.51 | Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cnn(C4CCNCC4)c3)nc1N2C | Homo sapiens | CHEMBL5096564 | assay format |
| CHEMBL3326006 |  |
IC50 | = | 7.97 | nM | 476.67 | CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 | Homo sapiens | CHEMBL3363362 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 8.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3108328 | single protein format |
| CHEMBL5204647 |  |
IC50 | = | 9.1 | nM | 504.66 | CCS(=O)(=O)c1ccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)cc1 | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL4442620 |  |
IC50 | < | 10.0 | nM | 430.45 | C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1C(F)(F)F | Homo sapiens | CHEMBL5096567 | single protein format |
| CHEMBL4569508 |  |
IC50 | = | 15.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479759 | assay format |
| CHEMBL5175737 |  |
IC50 | = | 15.0 | nM | 414.47 | Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3ccc4c(c3)NC(=O)CC4)nc1N2C | Homo sapiens | CHEMBL5096564 | assay format |