O60259 | KLK8_HUMAN | Kallikrein-8 (KLK8)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin | 34–252 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL239331 |  |
IC50 | = | 125.0 | nM | 496.5 | N=C(N)NCCCC(NC(=O)OCc1ccccc1)P(=O)(Oc1ccccc1)Oc1ccccc1 | Homo sapiens | CHEMBL3772679 | assay format |
| CHEMBL239535 |  |
IC50 | = | 170.0 | nM | 544.55 | N=C(N)Nc1ccc(CC(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772679 | assay format |
| CHEMBL3770794 |  |
IC50 | = | 170.0 | nM | 395.4 | N=C(N)Nc1ccc(CCP(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772679 | assay format |
| CHEMBL4206734 |  |
IC50 | = | 210.0 | nM | 458.52 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cc(C(=N)N)ccc12 | Homo sapiens | CHEMBL4201845 | assay format |
| CHEMBL238707 |  |
IC50 | = | 790.0 | nM | 515.51 | N=C(N)c1ccc(C(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3772679 | assay format |