O60235 | TM11D_HUMAN | Transmembrane protease serine 11D (TMPRSS11D)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 187~412 | |
| PF01390 | SEA - SEA domain | 49~152 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1809213 |  |
Ki | = | 13.0 | nM | 570.72 | N=C(N)NCCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809250 |  |
Ki | = | 14.0 | nM | 501.66 | CCC(NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809251 |  |
Ki | = | 15.0 | nM | 515.68 | CCC[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1229259 |  |
Ki | = | 19.0 | nM | 556.69 | N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809252 |  |
Ki | = | 22.0 | nM | 515.68 | CC(C)[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809253 |  |
Ki | = | 23.0 | nM | 529.71 | CC[C@H](C)[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809254 |  |
Ki | = | 30.0 | nM | 487.63 | C[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809256 |  |
Ki | = | 34.0 | nM | 503.63 | N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](CO)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809214 |  |
Ki | = | 36.0 | nM | 585.73 | CC(C)(C)OC(=O)CC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809215 |  |
Ki | = | 38.0 | nM | 571.7 | CC(C)(C)OC(=O)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809216 |  |
Ki | = | 40.0 | nM | 528.68 | N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809257 |  |
Ki | = | 47.0 | nM | 529.71 | CC(C)C[C@H](NCc1ccc(C(=N)N)cc1)C(=O)[C@@H](CCCNC(=N)N)NS(=O)(=O)Cc1ccccc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809258 |  |
Ki | = | 57.0 | nM | 563.73 | N=C(N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809218 |  |
Ki | = | 63.0 | nM | 561.71 | N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809241 |  |
Ki | = | 68.0 | nM | 597.74 | N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCC(=O)N2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809219 |  |
Ki | = | 76.0 | nM | 499.64 | CC(C)[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL252937 |  |
Ki | = | 78.0 | nM | 477.54 | N=C(N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809220 |  |
Ki | = | 98.0 | nM | 547.68 | N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1229261 |  |
Ki | = | 108.0 | nM | 553.73 | N=C(N)c1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC2CCCCC2)NS(=O)(=O)Cc2ccccc2)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |
| CHEMBL1809234 |  |
Ki | = | 120.0 | nM | 513.66 | CC(C)C[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(C(=N)N)cc1 | Homo sapiens | CHEMBL1810428 | single protein format |