O60218 | AK1BA_HUMAN | Aldo-keto reductase family 1 member B10 (AKR1B10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00248 | Aldo_ket_red - Aldo/keto reductase family | 17~292 |
3D structures mapped by conservation among orthologs
[ Domain: "TIM barrels" // Aldo_ket_red ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4089817 |  |
IC50 | = | 3.5 | nM | 341.34 | O=C(NCCCc1ccc(F)cc1)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL4081954 |  |
IC50 | = | 4.2 | nM | 339.35 | O=C(NCCCc1ccc(O)cc1)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL2440417 |  |
IC50 | = | 4.7 | nM | 400.43 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NCc2ccccc2)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL1172665 |  |
IC50 | = | 6.0 | nM | 387.4 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)Nc2ccccn2)cc1 | Homo sapiens | CHEMBL1174247 | assay format |
| CHEMBL4060049 |  |
IC50 | = | 6.0 | nM | 341.34 | O=C(NCCCc1cccc(F)c1)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL1940400 |  |
IC50 | = | 6.2 | nM | 328.36 | COc1cc(O)ccc1/C=C/C(=O)OCCCc1cccc(O)c1 | Homo sapiens | CHEMBL1942331 | assay format |
| CHEMBL4098452 |  |
IC50 | = | 6.4 | nM | 339.35 | O=C(NCCCc1ccccc1O)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL2440422 |  |
IC50 | = | 6.8 | nM | 373.37 | O=C(Nc1ccccn1)c1cc2ccc(O)cc2o/c1=N\c1ccc(O)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL4062779 |  |
IC50 | = | 7.0 | nM | 337.38 | Cc1ccc(CCCNC(=O)c2cc3ccc(O)cc3oc2=O)cc1 | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL4089816 |  |
IC50 | = | 7.5 | nM | 444.49 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NCCCc2cccc(O)c2)cc1 | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL2440423 |  |
IC50 | = | 7.6 | nM | 401.38 | O=C(O)c1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)Nc2ccccn2)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL4068704 |  |
IC50 | = | 7.8 | nM | 359.33 | O=C(NCCCc1cc(F)cc(F)c1)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL4071421 |  |
IC50 | = | 8.3 | nM | 339.35 | O=C(NCCCc1cccc(O)c1)c1cc2ccc(O)cc2oc1=O | Homo sapiens | CHEMBL4020427 | single protein format |
| CHEMBL2440424 |  |
IC50 | = | 8.6 | nM | 371.4 | Cc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)Nc2ccccn2)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL2440416 |  |
IC50 | = | 8.8 | nM | 368.39 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NCCCO)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL1940399 |  |
IC50 | = | 9.0 | nM | 328.36 | COc1cc(O)ccc1/C=C/C(=O)OCCCc1ccccc1O | Homo sapiens | CHEMBL1942331 | assay format |
| CHEMBL2440411 |  |
IC50 | = | 9.7 | nM | 352.39 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NC(C)C)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL2440414 |  |
IC50 | = | 11.0 | nM | 392.46 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NC2CCCCC2)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL2440415 |  |
IC50 | = | 11.0 | nM | 354.36 | COc1ccc(/N=c2\oc3cc(O)ccc3cc2C(=O)NCCO)cc1 | Homo sapiens | CHEMBL2444357 | assay format |
| CHEMBL4084456 |  |
IC50 | = | 11.0 | nM | 353.37 | COc1ccc(CCCNC(=O)c2cc3ccc(O)cc3oc2=O)cc1 | Homo sapiens | CHEMBL4020427 | single protein format |