O43924 | PDE6D_HUMAN | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05351 | GMP_PDE_delta - GMP-PDE, delta subunit | 10~149 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // GMP_PDE_delta ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4440294 |  |
IC50 | = | 21.0 | nM | 499.68 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccc(N(C)C)cc3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4459864 |  |
IC50 | = | 24.0 | nM | 542.71 | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)NC4CCCCC4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4527667 |  |
IC50 | = | 25.0 | nM | 537.65 | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cccnc4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4555739 |  |
IC50 | = | 25.2 | nM | 536.64 | COc1ccc(CCc2nnc(-c3ccc(OC(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4532027 |  |
IC50 | = | 26.4 | nM | 550.66 | CCC(Oc1ccc(-c2nnc(CCc3ccc(OC)cc3)n2Cc2ccccc2)cc1)C(=O)Nc1cnn(C)c1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4548659 |  |
IC50 | = | 27.0 | nM | 474.61 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccc(F)cc3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4514611 |  |
IC50 | = | 27.3 | nM | 540.65 | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4536719 |  |
IC50 | = | 30.0 | nM | 462.66 | CC(C)Cc1nnc(SCc2ccc(C(=O)NC3CCCCC3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4440110 |  |
IC50 | = | 33.0 | nM | 474.61 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccccc3F)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4589625 |  |
IC50 | = | 33.6 | nM | 550.66 | COc1ccc(CCc2nnc(-c3ccc(OC(C)(C)C(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4588289 |  |
IC50 | = | 35.0 | nM | 456.62 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccccc3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4566147 |  |
IC50 | = | 37.0 | nM | 474.61 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3cccc(F)c3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4585643 |  |
IC50 | = | 39.0 | nM | 532.71 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccc(-c4ccccc4)cc3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4443518 |  |
IC50 | = | 40.3 | nM | 554.68 | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4cc(C)nn4C)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4449262 |  |
IC50 | = | 40.9 | nM | 522.61 | COc1ccc(CCc2nnc(-c3ccc(OCC(=O)Nc4cnn(C)c4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4439169 |  |
IC50 | = | 41.1 | nM | 579.73 | COc1ccc(CSc2nnc(-c3ccc(OCC(=O)Nc4ccc(N(C)C)cc4)cc3)n2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4443194 |  |
IC50 | = | 43.0 | nM | 486.64 | COc1ccc(NC(=O)c2ccc(CSc3nnc(CC(C)C)n3Cc3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4590921 |  |
IC50 | = | 61.0 | nM | 524.61 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3cccc(C(F)(F)F)c3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4538447 |  |
IC50 | = | 64.0 | nM | 524.61 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccc(C(F)(F)F)cc3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |
| CHEMBL4450839 |  |
IC50 | = | 113.0 | nM | 507.66 | CC(C)Cc1nnc(SCc2ccc(C(=O)Nc3ccc4ncccc4c3)cc2)n1Cc1ccccc1 | Homo sapiens | CHEMBL4412200 | cell-based format |